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Migraine: A Spectrum of Ideas

Merton Sandler and Geralyn M. Collins

Abstract

Thirty per cent of all women and ten per cent of all men experience migraine. This crippling illness does not kill, but its high morbidity poses a massive economic problem and gives rise to considerable suffering. Its main manifestation, headache, is subjective, and there are no animal models. This makes traditional research approaches difficult, and has led to a variety of research strategies. Chapters here present the numerous advances that have been made over the past two decades in our understanding of this disorder, and discuss in depth the position of migraine research today and the dire ... More

Keywords: migraine, crippling illness, high morbidity, economic problem, headache, animal models, traditional research approaches, research strategies, migraine research, disorder

Bibliographic Information

Print publication date: 1990 Print ISBN-13: 9780192618108
Published to Oxford Scholarship Online: March 2012 DOI:10.1093/acprof:oso/9780192618108.001.0001

Authors

Affiliations are at time of print publication.

Merton Sandler, editor
University of London

Geralyn M. Collins, editor

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Contents

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Front Matter

Title Pages

Contributors

1. Introduction

Merton Sandler

2. The nature of migraine: do we need to invoke slow neurochemical processes?

J.N. Blau

3. Contribution of experimental studies to understanding the pathophysiology of migraine

J.W. Lance, G.A. Lambert, P.J. Goadsby, and A.S. Zagami

4. Genetic epidemiology of migraine

Kathleen R. Merikangas

5. A possible role of endothelial vasorelaxants in the pathogenesis of migraine

Ryszard J. Gryglewski, and John R. Vane

6. A classification of peripheral analgesics based upon their mode of action

Sérgio H. Ferreira

7. Vasomotor functions of trigeminovascular fibres: inferences from lesion studies

Michael A. Moskowitz, Damianos E. Sakas, Michihisa Kano, Hermes A. Kontos, and Enoch P. Wei

8. Regional cerebral blood flow in migraine

Jes Olesen, Tom Skyhøj Olsen, and Lars Friberg

9. Migraine pathogenesis examined with contemporary techniques for analysing brain function

K.M.A. Welch

10. The superior pericarotid cavernous sinus plexus and cluster headaches

Michael A. Moskowitz, and M. Gabriella Buzzi

11. 5-HT in migraine: evidence from 5-HT receptor antagonists for a neuronal aetiology

J.R. Fozard

12. 5-HT in migraine: evidence from 5-HT1-like receptor agonists for a vascular aetiology

P.P.A. Humphrey, W. Feniuk, and M.J. Perren

13. Behavioural effects of m-chlorophenylpiperazine (m-CPP), a reported migraine precipitant

G. Curzon, G.A. Kennett, K. Shah, and P. Whitton

14. 5-HT receptors and migraine

Pramod R. Saxena

15. Is there still a case for the shunt hypothesis in migraine?

Pramod R. Saxena

16. General discussion I

Merton Sandler, and Geralyn M. Collins

17. Peptidergic mechanisms in human intracranial and extracranial arteries

Lars Edvinsson, Inger Jansen, and Rolf Uddman

18. Novel agents affecting enkephalinergic and histaminergic transmissions in brain

J.C. Schwartz, B. Giros, C. Gros, C. Llorens-Cortes, J.M. Arrang, M. Garbarg, and H. Pollard

19. The biochemical basis of migraine predisposition

Vivette Glover, and Merton Sandler

20. Depression and migraine

Kathleen R. Merikangas, and Jules Angst

21. Pain, headache, and depression: a discussion

Richard C. Peatfield

22. A note on the role of platelets in migraine: a personal view

Richard C. Peatfield

23. Differential abnormalities in signal transduction in migraine and cluster headache

J. de Belleroche

24. The current status of migraine therapy

F. Clifford Rose

25. Treatment: where are we going?

Albrecht Ziegler

26. General discussion II

Merton Sandler, and Geralyn M. Collins

27. The neurovascular basis of migraine: some concluding thoughts

James W. Lance

End Matter

Index