Jump to ContentJump to Main Navigation
Migraine: A Spectrum of Ideas$
Users without a subscription are not able to see the full content.

Merton Sandler and Geralyn M. Collins

Print publication date: 1990

Print ISBN-13: 9780192618108

Published to Oxford Scholarship Online: March 2012

DOI: 10.1093/acprof:oso/9780192618108.001.0001

Show Summary Details
Page of

PRINTED FROM OXFORD SCHOLARSHIP ONLINE (oxford.universitypressscholarship.com). (c) Copyright Oxford University Press, 2021. All Rights Reserved. An individual user may print out a PDF of a single chapter of a monograph in OSO for personal use. date: 31 July 2021

Peptidergic mechanisms in human intracranial and extracranial arteries

Peptidergic mechanisms in human intracranial and extracranial arteries

(p.207) 17. Peptidergic mechanisms in human intracranial and extracranial arteries
Migraine: A Spectrum of Ideas

Lars Edvinsson

Inger Jansen

Rolf Uddman

Oxford University Press

Migraine attacks are conventionally thought to involve a dysfunction in the regulation of tone in intra- and extracranial blood vessels. A number of agents have been suggested as responsible for the altered vasomotor responses seen in conjunction with migraine attacks. Previous histochemical studies have shown that human cerebral arteries are surrounded by adrenergic and cholinergic nerve fibres. In addition, peptide-containing nerve fibres, such as neuropeptide Y (NPY), vasoactive intestinal peptide (VIP), substance P (SP), and calcitonin gene-related peptide (CGRP), have been observed around the cerebral blood vessels of laboratory animals. Few studies have been carried out on human temporal and cerebral arteries, but none on meningeal arteries. This chapter examines the distribution of NPY-, VIP-, SP- and CGRP-immunoreactive fibres around the three types of human cranial arteries and compared the pharmacological effects of the perivascularly located neuropeptides on arterial segments.

Keywords:   extracranial blood vessels, migraine attack, vasoactive intestinal peptide, neuropeptide Y, calcitonin gene-related peptide, neuropeptides

Oxford Scholarship Online requires a subscription or purchase to access the full text of books within the service. Public users can however freely search the site and view the abstracts and keywords for each book and chapter.

Please, subscribe or login to access full text content.

If you think you should have access to this title, please contact your librarian.

To troubleshoot, please check our FAQs , and if you can't find the answer there, please contact us .