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Migraine: A Spectrum of Ideas$
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Merton Sandler and Geralyn M. Collins

Print publication date: 1990

Print ISBN-13: 9780192618108

Published to Oxford Scholarship Online: March 2012

DOI: 10.1093/acprof:oso/9780192618108.001.0001

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PRINTED FROM OXFORD SCHOLARSHIP ONLINE (oxford.universitypressscholarship.com). (c) Copyright Oxford University Press, 2021. All Rights Reserved. An individual user may print out a PDF of a single chapter of a monograph in OSO for personal use. date: 27 July 2021

Novel agents affecting enkephalinergic and histaminergic transmissions in brain

Novel agents affecting enkephalinergic and histaminergic transmissions in brain

(p.218) 18. Novel agents affecting enkephalinergic and histaminergic transmissions in brain
Migraine: A Spectrum of Ideas

J.C. Schwartz

B. Giros

C. Gros

C. Llorens-Cortes

J.M. Arrang

M. Garbarg

H. Pollard

Oxford University Press

Progress in cephalalgia therapy may be anticipated from the development of novel classes of drugs that affect either the transmission of pain messages or the control of vascular mechanisms in the brain. A valuable strategy for achieving such an aim consists in identifying new molecular targets that are critically involved in neurotransmitter metabolism or actions. This line has been followed in recent years in our laboratory to identify the mechanisms responsible for opioid peptide inactivation, and for the control of histamine release from its cerebral neurones. In both cases, relevant molecular targets were identified — that is, two ‘neuropeptidases’ responsible for enkephalin breakdown, and the H3 autoreceptor responsible for the control of histamine synthesis and release. Agents able to interact selectively and potently with these various targets have been rationally designed to help us to study the corresponding control mechanisms. These agents may constitute new drugs to be used in human therapeutics.

Keywords:   enkephalinergic transmissions, histaminergic transmissions, H3 autoreceptor, pain messages, vascular mechanisms, neuropeptidases

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