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5-Hydroxytryptamine in Psychiatry – A Spectrum of Ideas - Oxford Scholarship Online
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5-Hydroxytryptamine in Psychiatry: A Spectrum of Ideas

Merton Sandler, Alec Coppen, and Sara Harnett


The field of research in 5-hydroxytryptamine has exploded into furious activity over the past decade and nowhere have the implications been more far reaching than in psychiatry. Thanks largely to the introduction of radioligand-binding techniques, a bewildering variety of 5-hydroxytryptamine receptors has been revealed, and powerful new families of centrally active drugs have emerged. The importance of these new discoveries for psychiatric practice can hardly be exaggerated. To mention but one example, our understanding, and with it the treatment, of obsessive-compulsive disorder has been tran ... More

Keywords: 5-hydroxytryptamine, psychiatry, radioligand-binding techniques, receptors, centrally-active drugs, psychiatric practice, obsessive-compulsive disorder, psychiatric illness, CINP, President's Workshop

Bibliographic Information

Print publication date: 1991 Print ISBN-13: 9780192620118
Published to Oxford Scholarship Online: March 2012 DOI:10.1093/acprof:oso/9780192620118.001.0001


Affiliations are at time of print publication.

Merton Sandler, editor
Queen Charlotte's and Chelsea Hospital

Alec Coppen, editor
MRC Neuropsychiatry Laboratory

Sara Harnett, editor

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Front Matter

1. Introduction

Merton Sandler

2. An overview of 5-hydroxytryptamine receptor families

Stephen J. Peroutka, and Anne W. Schmidt

7. The role of 5-HT in migraine: disentangling the links with depression

Vivette Glover, Joan Jarman, and Merton Sandler

12. Experimental tests of the 5-HT receptor imbalance theory of affective disturbance

J. F. W. Deakin, F. S. Guimaraes, M. Wang, and R. Hensman

14. Neuroendocrine serotonergic challenges in clinical research

Juan J. López-Ibor, Jerόnimo Sáiz-Ruiz, Leticia Moral, Isabel Moreno, and Rosa Viñas

19. Monoamines, glucose metabolism, and impulse control

Markku Linnoila, and Matti Virkkunen

23. 5-HT3 receptor antagonists and their potential in psychiatric disorders

Michael G. Palfreyman, Stephen M. Sorensen, Albert A. Carr, Hsien C. Cheng, and Mark W. Dudley

25. Summary

Arvid Carlsson

End Matter