Jump to ContentJump to Main Navigation
Brain Function and Psychotropic Drugs$
Users without a subscription are not able to see the full content.

Heather Ashton

Print publication date: 1992

Print ISBN-13: 9780192622426

Published to Oxford Scholarship Online: March 2012

DOI: 10.1093/acprof:oso/9780192622426.001.0001

Show Summary Details
Page of

PRINTED FROM OXFORD SCHOLARSHIP ONLINE (oxford.universitypressscholarship.com). (c) Copyright Oxford University Press, 2021. All Rights Reserved. An individual user may print out a PDF of a single chapter of a monograph in OSO for personal use. date: 09 March 2021

Depression and mania: clinical features and brain mechanisms

Depression and mania: clinical features and brain mechanisms

(p.226) (p.227) 11 Depression and mania: clinical features and brain mechanisms
Brain Function and Psychotropic Drugs

Heather Ashton

Oxford University Press

It is clear, from the clinical manifestations and observed physiological changes, that brain systems for arousal and sleep, reward and punishment, and learning and memory are involved in depression and mania, but the central feature is an alteration of mood. Similar mood changes may occur in organic brain disease, and it is possible that neuropathological changes underlie major affective disorders. However, in many cases these conditions appear to result from a largely reversible, though recurrent, functional disorder of brain systems controlling emotional tone. This chapter discusses the present evidence which points to a dysfunction of the limbic system, particularly in pathways subserving reward and punishment. Depression and mania can thus be viewed as disorders of reward and punishment systems, with features in common with drug dependence and chronic pain syndromes.

Keywords:   depression, mania, reward systems, neuropathological changes, limbic system, punishment systems, chronic pain, drug dependence

Oxford Scholarship Online requires a subscription or purchase to access the full text of books within the service. Public users can however freely search the site and view the abstracts and keywords for each book and chapter.

Please, subscribe or login to access full text content.

If you think you should have access to this title, please contact your librarian.

To troubleshoot, please check our FAQs , and if you can't find the answer there, please contact us .