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Antenatal and Neonatal Screening$
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Nicholas Wald and Ian Leck

Print publication date: 2000

Print ISBN-13: 9780192628268

Published to Oxford Scholarship Online: September 2009

DOI: 10.1093/acprof:oso/9780192628268.001.0001

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Tests using single markers

Tests using single markers

(p.3) 1 Tests using single markers
Antenatal and Neonatal Screening

Howard S. Cuckle

Nicholas Wald

Oxford University Press

This chapter describes screening based on the measurement of a single variable. Before considering the screening test in detail, it is necessary to consider the disorder for which screening is being carried out, its definition, its prevalence, its natural history, and the efficacy of its treatment or prevention. Information on the overlap of test values from affected and unaffected individuals is necessary to determine detection rates and false-positive rates, which, together with data on prevalence, permit the estimation of the risk of being affected. This information is also needed for subsequent screening or diagnostic tests.

Keywords:   screening tests, diagnostic tests, monitoring, single variables, detection rate, false positive rate

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