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Antenatal and Neonatal Screening$
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Nicholas Wald and Ian Leck

Print publication date: 2000

Print ISBN-13: 9780192628268

Published to Oxford Scholarship Online: September 2009

DOI: 10.1093/acprof:oso/9780192628268.001.0001

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Amniocentesis and chorionic villus sampling

Amniocentesis and chorionic villus sampling

(p.470) 19 Amniocentesis and chorionic villus sampling
Antenatal and Neonatal Screening

Christine Gosden

Ann Tabor

Ian Leck

Adrian Grant

Zarko Alfirevic

Nicholas Wald

Oxford University Press

This chapter reviews amniocentesis and chorionic villus sampling (CVS) to obtain tissue of the same genetic origin as the fetus for diagnostic purposes (most often testing for chromosomal abnormalities) without removing any tissue from the fetus itself. Second-trimester amniocentesis is a very effective test: failure to make a diagnosis is very rare. It involves a small risk of fetal loss, estimated at about 1 in 100 pregnancies. CVS is somewhat less effective, comparably safe if performed transabdominally, but less so if performed transvaginally.

Keywords:   antenatal diagnosis, amniocentesis, chorionic villus sampling, chromosomal abnormalities

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