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Antenatal and Neonatal Screening$
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Nicholas Wald and Ian Leck

Print publication date: 2000

Print ISBN-13: 9780192628268

Published to Oxford Scholarship Online: September 2009

DOI: 10.1093/acprof:oso/9780192628268.001.0001

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PRINTED FROM OXFORD SCHOLARSHIP ONLINE (oxford.universitypressscholarship.com). (c) Copyright Oxford University Press, 2021. All Rights Reserved. An individual user may print out a PDF of a single chapter of a monograph in OSO for personal use. date: 16 June 2021

Neural tube defects

Neural tube defects

(p.61) 3 Neural tube defects
Antenatal and Neonatal Screening

Nicholas Wald

Oxford University Press

Antenatal screening and diagnosis for neural tube defects involves the application of two methods — maternal serum alphafetoprotein (AFP) followed by amniotic fluid AFP measurement, and ultrasound examination of the fetus. The present challenge in screening is to integrate the two methods into a coherent screening strategy. This chapter quantifies the screening and diagnostic performance of the different methods, and offers a view on how they could be integrated.

Keywords:   antenatal screening, antenatal diagnosis, maternal serum alphafetoprotein, amniotic fluid alphafetoprotein, ultrasound, neural trube defects

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