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Where's the Evidence?Debates in Modern Medicine$
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William A. Silverman

Print publication date: 1999

Print ISBN-13: 9780192630889

Published to Oxford Scholarship Online: September 2009

DOI: 10.1093/acprof:oso/9780192630889.001.0001

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Champing at the bit

Champing at the bit

(p.130) 31 Champing at the bit
Where's the Evidence?

William A. Silverman

Oxford University Press

This chapter presents a 1995 commentary on the development of sequential designs for ‘continuous peeking’ in clinical trials, and the use of independent monitoring committees to conduct interim analysis of results. In recent years, such close oversight spawned its own set of problems — increasing pressure on trialists to stop enrolling patients when preliminary trends become apparent, before the study design call for termination of the trials.

Keywords:   medical trials, clinical trials, monitoring, study design

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