Jump to ContentJump to Main Navigation
Receptor and Ion-Channel TraffickingCell Biology of Ligand-Gated and Voltage-Sensitive Ion Channels$
Users without a subscription are not able to see the full content.

Stephen J. Moss and Jeremy Henley

Print publication date: 2002

Print ISBN-13: 9780192632241

Published to Oxford Scholarship Online: March 2012

DOI: 10.1093/acprof:oso/9780192632241.001.0001

Show Summary Details
Page of

PRINTED FROM OXFORD SCHOLARSHIP ONLINE (oxford.universitypressscholarship.com). (c) Copyright Oxford University Press, 2020. All Rights Reserved. An individual user may print out a PDF of a single chapter of a monograph in OSO for personal use. date: 25 October 2020

Voltage-gated sodium channels

Voltage-gated sodium channels

(p.2) (p.3) Chapter 1 Voltage-gated sodium channels
Receptor and Ion-Channel Trafficking

Misbah Malik-Hall

John N. Wood

Kenji Okuse

Oxford University Press

It is known that the neuron-specific pattern of transcription of some voltage-gated sodium channels (VGSCs) is regulated by a specific sequence, the NRSE/RE1 (neuron-restricted silencing element) and its cognate binding protein. In addition, a role for accessory subunits in high-level channel expression and channel anchoring with respect to extracellular signals is also now established. More recently, signals ranging from growth factors such as GDNF to nerve damage or demyelinating diseases have been shown to alter the cohort of sodium (Na) channels expressed in neurons and may also alter their spatial pattern of expression. This chapter focuses on the possible regulatory role of accessory subunits that have been found to associate with Na channel α subunits, and factors that alter channel expression.

Keywords:   VGSCs, demyelinating diseases, extracellular signals, nerve damage, sodium channels, neurons, channel expression

Oxford Scholarship Online requires a subscription or purchase to access the full text of books within the service. Public users can however freely search the site and view the abstracts and keywords for each book and chapter.

Please, subscribe or login to access full text content.

If you think you should have access to this title, please contact your librarian.

To troubleshoot, please check our FAQs , and if you can't find the answer there, please contact us .