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Receptor and Ion-Channel TraffickingCell Biology of Ligand-Gated and Voltage-Sensitive Ion Channels$
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Stephen J. Moss and Jeremy Henley

Print publication date: 2002

Print ISBN-13: 9780192632241

Published to Oxford Scholarship Online: March 2012

DOI: 10.1093/acprof:oso/9780192632241.001.0001

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The assembly and targeting of potassium channels

The assembly and targeting of potassium channels

(p.28) Chapter 2 The assembly and targeting of potassium channels
Receptor and Ion-Channel Trafficking

Andrew Tinker

Oxford University Press

Potassium channels are one of the largest ion channel gene families. They are present in nearly all living organisms from bacteria through to man. There are a number of separate families of pore-forming subunit (ex subunit) characterized by distinct biophysical properties and often interacting with unique modulatory proteins (α subunits) distinct from the pore-forming subunit. This chapter discusses what is known of the assembly and targeting of these complexes. To state the obvious, there have also been enormous advances in other aspects of these channels. Issues such as the molecular basis of ion conduction and gating are dealt with briefly in relation to how they impinge on the theme of the chapter.

Keywords:   potassium channels, gating, ion conduction, ion channels, ex subunit, protein interactions

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