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Receptor and Ion-Channel TraffickingCell Biology of Ligand-Gated and Voltage-Sensitive Ion Channels$
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Stephen J. Moss and Jeremy Henley

Print publication date: 2002

Print ISBN-13: 9780192632241

Published to Oxford Scholarship Online: March 2012

DOI: 10.1093/acprof:oso/9780192632241.001.0001

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Assembly and targeting of voltage-dependent calcium channels

Assembly and targeting of voltage-dependent calcium channels

(p.58) Chapter 3 Assembly and targeting of voltage-dependent calcium channels
Receptor and Ion-Channel Trafficking

Annette C. Dolphin

Oxford University Press

Ion channel trafficking, like that of other heteromeric membrane proteins, proceeds in a number of stages, and in the case of voltage-dependent calcium channels (VDCCs) very little is known about any of these processes. Starting from the initial translation of subunit mRNA into protein, a number of distinct but interdependent processes must occur, including the translocation of transmembrane subunits into the membrane of the endoplasmic reticulum, post-translational modification and the folding of individual subunits, oligomerization and association with auxiliary subunits, and trafficking through the endoplasmic reticulum and trans-Golgi network. All these are likely to occur on overlapping timescales, and are not expected to be independent processes.

Keywords:   VDCCs, ion channel trafficking, subunit mRNA, translation, oligomerization, translocation, transmembrane subunits

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