Chapter 6 Ampa/kainate receptors
- Receptor and Ion-Channel Trafficking
Nicole L. Stricker
Richard L. Huganir
- Oxford University Press
The three major types of ionotropic glutamate receptors are the N-methyl-d-aspartate (NMDAR), α-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPAR), and kainate (KAR) receptors. AM PARs and KARs mediate fast excitatory transmission, whereas NMDARs mediate a slower component of synaptic transmission which is important for modulation of synaptic and neuronal function. This chapter focuses on the mechanisms of AMPA and kainate glutamate receptor assembly, synaptic localization, and surface expression.
ionotropic glutamate receptors, NMDAR, AMPAR, kainate glutamate receptors, synaptic localization, surface expression, neuronal function
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