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Receptor and Ion-Channel TraffickingCell Biology of Ligand-Gated and Voltage-Sensitive Ion Channels$
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Stephen J. Moss and Jeremy Henley

Print publication date: 2002

Print ISBN-13: 9780192632241

Published to Oxford Scholarship Online: March 2012

DOI: 10.1093/acprof:oso/9780192632241.001.0001

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Structure, assembly and targeting of glycine receptors

Structure, assembly and targeting of glycine receptors

(p.171) Chapter 8 Structure, assembly and targeting of glycine receptors
Receptor and Ion-Channel Trafficking

Kirsten Harvey

Jeska von der Nuell

Robert J. Harvey

Oxford University Press

Glycine receptors (GlyRs) are widely known to be responsible for the control of motor and sensory pathways in the spinal cord and brain stem, and are a major target for modulation by alcohol, volatile general anaesthetics, and inhaled drugs of abuse. Several developmentally and regionally regulated GlyR isoforms exist, which result from the differential expression of five genes coding for ligand-binding GlyR α (α1–α4) and structural β subunits. Additional GlyR subunit diversity arises from alternative splicing of the α1, α2, α3, and β subunit transcripts. Sequence comparisons have shown that the GlyR is part of a ligand-gated ion channel superfamily which includes nicotinic acetylcholine receptors (nAChRs), γ-aminobutyric acid type A (GABAA) and C (GABAC) receptors, serotonin type 3 (5HT3) receptors and glutamate-gated chloride channels from invertebrates.

Keywords:   glycine receptors, motor pathways, sensory pathways, spinal cord, GlyR isoforms, gene coding, transcripts

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