Effects of N-Methyl-d-Aspartate Receptor Antagonists on Vestibular Compensation in the Guinea Pig: In Vivo and In Vitro Studies

Paul F. Smith; Cynthia L. Darlington

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The Head-Neck Sensory Motor System

Alain Berthoz, Werner Graf, and P. P. Vidal

Print publication date: 1992

Print ISBN-13: 9780195068207

Published to Oxford Scholarship Online: March 2012

DOI: 10.1093/acprof:oso/9780195068207.001.0001

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ContentsFRONT MATTER

Title Pages
Contributors
Preface
Investigations Relating to the Head-Neck Movement System Around the Time of the French Revolution (1789)
Part I The Head-Neck System from an Anthropologic Viewpoint
- Chapter 1 The Upright Head in Hominid Evolution
Part II Evolution of the Head-Neck Movement System
- Chapter 2 Why Develop a Neck?
- Chapter 3 Evolution of the Dorsal Muscles of the Spine in Light of Their Adaptation to Gravity Effects
- Chapter 4 Modeling of the Craniofacial Architecture during Ontogenesis and Phylogenesis
Part III Comparative Aspects of the Head-Neck Movement System
- A. Invertebrates
- B. Vertebrates
Part IV Embryology and Ontogeny of the Head-Neck Movement System
- Chapter 14 Development of the Vertebral Joints (C3 through T2) in Man
- Chapter 15 Head Position and Posture in Newborn Infants
- Chapter 16 Head-Trunk Coordination and Locomotor Equilibrium in 3-to 8-Year-Old Children
Part V Architecture of the Head-Neck Movement System
- A. Bones and Muscles
- B. Models and Theories
Part VI Sensors of the Head-Neck Movement System
- Chapter 24 Somatosensory Pathways from the Neck
- Chapter 25 Physiologic Properties and Central Actions of Neck Muscle Spindles
- Chapter 26 Excitatory and Inhibitory Mechanisms Involved in the Dynamic Control of Posture during the Cervicospinal Reflexes
- Chapter 27 Suppression of Cervical Afferents Impairs Visual Cortical Cells Development
- Chapter 28 Eye and Neck Proprioceptive Messages Contribute to the Specification of Gaze Direction in Visually Oriented Activities
- Chapter 29 Influence of Neck Receptor Stimulation on Eye Rotation and on the Subjective Vertical: Experiments on the Tilt Table, under Water, and in Weightlessness
- Chapter 30 Cervico-ocular Reflexes with and without Simultaneous Vestibular Stimulation in Rabbits
- Chapter 31 Vestibular and Optokinetic Asymmetries in the Ocular and Cervical Reflexes
- Chapter 32 Cervicovestibular Interactions in Coriolis-Like Effects
- Chapter 33 Gravitational, Inertial, and Coriolis Force Influences on Nystagmus, Motion Sickness, and Perceived Head Trajectory
- Chapter 34 Head Position versus Head Motion in the Inhibition of Horizontal Postrotary Nystagmus
Part VII Neuronal Mechanisms of the Sensory-Motor Transformations in the Head-Neck Movement System
- A. Spinal Mechanisms
  - Chapter 35 Intrinsic Properties of Neck Motoneurons
  - Chapter 36 Organization of the Motor Nuclei Innervating Epaxial Muscles in the Neck and Back
- B. Vestibular Neurons
- C. Collicular and Reticular Neurons
- D. Interstitial Nucleus of Cajal and Beyond
Part VIII Synergies and Strategies of Head Movements and Gaze Control
- A. Head Movement Control
- B. Orienting and Stabilizing Eye and Head Movements
- C. Timing and Prediction
- D. Linear Movement Analysis
  - Chapter 74 Decoding of Optic Flow by the Primate Optokinetic System
  - Chapter 75 Eye Movements and Visual-Vestibular Interactions during Linear Head Motion
- E. Perception
- F. Eye-Head Coordination and Reflex Behavior
Part IX Head Movement during Posture, Locomotion, and Complex Movements
- Chapter 86 What about the So-Called Neck Reflexes in Humans?
- Chapter 87 Do Head Position and Active Head Movements Influence Postural Stability?
- Chapter 88 Significance of Muscle Proprioceptive and Vestibulospinal Reflexes in the Control of Human Posture
- Chapter 89 Influence of Tactile Cues on Visually Induced Postural Reactions
- Chapter 90 Differential Influence of Vertical Head Posture during Walking
- Chapter 91 Control of Head Stability and Gaze during Locomotion in Normal Subjects and Patients with Deficient Vestibular Function
- Chapter 92 Head-Trunk Coordination in Man: Is Trunk Angular Velocity Elicited by a Support Surface Movement the Only Factor Influencing Head Stabilization?
- Chapter 93 Visual, Vestibular, and Somatosensory Control of Compensatory Gaze Nystagmus during Circular Locomotion
- Chapter 94 Different Patterns in Aiming Accuracy for Head-Movers and Non-Head Movers
- Chapter 95 Head Kinematics during Complex Movements
- Chapter 96 Head-Forelimb Movement Coordination and Its Rearrangement in the Course of Training in the Dog: Role of the Motor Cortex
- Chapter 97 Preferential Activation of the Sternocleidomastoid Muscles by the Ipsilateral Motor Cortex during Voluntary Rapid Head Rotations in Humans
Part X Disorders of the Head-Neck System
- A. Vestibular Disorders
- B. Neurologic Disorders
END MATTER
References
Index
Plates

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Effects of N-Methyl-d-Aspartate Receptor Antagonists on Vestibular Compensation in the Guinea Pig: In Vivo and In Vitro Studies

Chapter:: (p.631) Chapter 104 Effects of N-Methyl-D-Aspartate Receptor Antagonists on Vestibular Compensation in the Guinea Pig: In Vivo and In Vitro Studies
Source:: The Head-Neck Sensory Motor System
Author(s):: Paul F. Smith
Cynthia L. Darlington
Publisher:: Oxford University Press

DOI:10.1093/acprof:oso/9780195068207.003.0104

This study investigates the contribution of NMDA receptors to vestibular compensation for UL in the guinea pig using the NMDA receptor/channel antagonists. Three experimental approaches were taken to examine the effect of NMDA antagonists on vestibular compensation. The results imply that NMDA receptor antagonists interfere with vestibular compensation during a limited period following UL. It is found that noncompetitive NMDA antagonists MK801 have a binding site similar to dissociative anesthetics such as ketamine.

Keywords: NMDA antagonists, ketamine, vestibular compensation, NMDA receptor, dissociative anesthetics, binding site

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Alain Berthoz, Werner Graf, and P. P. Vidal

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Effects of N-Methyl-d-Aspartate Receptor Antagonists on Vestibular Compensation in the Guinea Pig: In Vivo and In Vitro Studies

Effects of N-Methyl-d-Aspartate Receptor Antagonists on Vestibular Compensation in the Guinea Pig: In Vivo and In Vitro Studies

Paul F. Smith

Cynthia L. Darlington