Effects of N-Methyl-d-Aspartate Receptor Antagonists on Vestibular Compensation in the Guinea Pig: In Vivo and In Vitro Studies
Effects of N-Methyl-d-Aspartate Receptor Antagonists on Vestibular Compensation in the Guinea Pig: In Vivo and In Vitro Studies
This study investigates the contribution of NMDA receptors to vestibular compensation for UL in the guinea pig using the NMDA receptor/channel antagonists. Three experimental approaches were taken to examine the effect of NMDA antagonists on vestibular compensation. The results imply that NMDA receptor antagonists interfere with vestibular compensation during a limited period following UL. It is found that noncompetitive NMDA antagonists MK801 have a binding site similar to dissociative anesthetics such as ketamine.
Keywords: NMDA antagonists, ketamine, vestibular compensation, NMDA receptor, dissociative anesthetics, binding site
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