Jump to ContentJump to Main Navigation
The AxonStructure, Function and Pathophysiology$
Users without a subscription are not able to see the full content.

Stephen G. Waxman, Jeffery D. Kocsis, and Peter K. Stys

Print publication date: 1995

Print ISBN-13: 9780195082937

Published to Oxford Scholarship Online: May 2009

DOI: 10.1093/acprof:oso/9780195082937.001.0001

Show Summary Details
Page of

PRINTED FROM OXFORD SCHOLARSHIP ONLINE (oxford.universitypressscholarship.com). (c) Copyright Oxford University Press, 2021. All Rights Reserved. An individual user may print out a PDF of a single chapter of a monograph in OSO for personal use. date: 21 October 2021

Voltage-clamp studies in axons: Macroscopic and single-channel currents

Voltage-clamp studies in axons: Macroscopic and single-channel currents

(p.257) 13 Voltage-clamp studies in axons: Macroscopic and single-channel currents
The Axon



Oxford University Press

This chapter describes macroscopic membrane currents measured in amphibian and mammalian nodes of Ranvier with the voltage-clamp method. These results are compared with those of single-channel recordings, which provide important data on channel characteristics in myelinated axons. The results obtained from the calculation of the action potentials with voltage-clamp data obtained from frog, rat, and human nerve fibers are also reviewed. It is shown that the properties of the various new ionic channel types detected with the patch-clamp technique help explain previously unsolved problems concerning the ionic basis of accommodation, resting potential, and various pathophysiological phenomena.

Keywords:   membrane currents, amphibians, mammals, nodes of Ranvier, voltage-clamp method, action potentials

Oxford Scholarship Online requires a subscription or purchase to access the full text of books within the service. Public users can however freely search the site and view the abstracts and keywords for each book and chapter.

Please, subscribe or login to access full text content.

If you think you should have access to this title, please contact your librarian.

To troubleshoot, please check our FAQs , and if you can't find the answer there, please contact us .