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The AxonStructure, Function and Pathophysiology$
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Stephen G. Waxman, Jeffery D. Kocsis, and Peter K. Stys

Print publication date: 1995

Print ISBN-13: 9780195082937

Published to Oxford Scholarship Online: May 2009

DOI: 10.1093/acprof:oso/9780195082937.001.0001

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PRINTED FROM OXFORD SCHOLARSHIP ONLINE (oxford.universitypressscholarship.com). (c) Copyright Oxford University Press, 2021. All Rights Reserved. An individual user may print out a PDF of a single chapter of a monograph in OSO for personal use. date: 21 October 2021

Modulation of axonal excitability by neurotransmitter receptors

Modulation of axonal excitability by neurotransmitter receptors

(p.281) 14 Modulation of axonal excitability by neurotransmitter receptors
The Axon



Oxford University Press

This chapter describes axonal regions in the mammalian nervous system that have well-defined neurotransmitter receptors and discusses their possible functional significance. It focuses on the axonal GABAa receptor, which may be the best studied neurotransmitter receptor on axons in mammals. The chapter reviews evidence for expression of GABAareceptors on certain axons and describes their electrophysiological properties and possible modulatory role on impulse conduction. Evidence is presented for the transient presence and release of astrocytically derived GABA and its functional GABAa receptors at a critical time during optic nerve development. A model is presented that could account for a trophic influence of axonal GABAA receptor activation on the development of optic nerve axons.

Keywords:   axonal regions, mammalian nervous system, GABA receptor, axons, neurotransmitter receptor

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