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The AxonStructure, Function and Pathophysiology$
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Stephen G. Waxman, Jeffery D. Kocsis, and Peter K. Stys

Print publication date: 1995

Print ISBN-13: 9780195082937

Published to Oxford Scholarship Online: May 2009

DOI: 10.1093/acprof:oso/9780195082937.001.0001

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Mechanisms of accommodation and adaptation in myelinated axons

Mechanisms of accommodation and adaptation in myelinated axons

(p.311) 16 Mechanisms of accommodation and adaptation in myelinated axons
The Axon


Oxford University Press

This chapter discusses accommodation in the nonspecialized parts of the axons of peripheral nerve. The term “accommodation” is taken to embrace both the processes that oppose the increase in axonal excitability caused by long-lasting, subthreshold depolarizing currents and also the processes of adaptation that limit repetitive firing to a maintained subthreshold current. In normal mammalian fibers, subthreshold accommodation is less important than often assumed, and closely related to electrotonic changes in membrane potential that depend on slow (Ks) and fast (Kf1) potassium channels. In depolarized fibers, inactivation of sodium channels plays a major role and accommodation becomes faster and stronger and less related to membrane potential. In hyperpolarized fibers, the passive cable properties become relatively more important and accommodation is weaker and delayed.

Keywords:   axons, peripheral nerve, subthreshold accommodation, mammalian fibers, depolarized fibers, hyperpolarized fibers

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