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The AxonStructure, Function and Pathophysiology$
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Stephen G. Waxman, Jeffery D. Kocsis, and Peter K. Stys

Print publication date: 1995

Print ISBN-13: 9780195082937

Published to Oxford Scholarship Online: May 2009

DOI: 10.1093/acprof:oso/9780195082937.001.0001

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PRINTED FROM OXFORD SCHOLARSHIP ONLINE (oxford.universitypressscholarship.com). (c) Copyright Oxford University Press, 2021. All Rights Reserved. An individual user may print out a PDF of a single chapter of a monograph in OSO for personal use. date: 22 October 2021

Axonal degeneration and disorders of the axonal cytoskeleton

Axonal degeneration and disorders of the axonal cytoskeleton

Chapter:
(p.375) 20 Axonal degeneration and disorders of the axonal cytoskeleton
Source:
The Axon
Author(s):

JOHN W. GRIFFIN

EDWIN B. GEORGE

SUNG-TSANG HSIEH

JONATHAN D. GLASS

Publisher:
Oxford University Press
DOI:10.1093/acprof:oso/9780195082937.003.0020

This chapter discusses cytoskeletal changes in axonal degeneration. It begins with a review of the organization of the normal axonal cytoskeleton, followed by a summary of the current understanding of Wallerian degeneration. It then considers the slowly evolving axonal degenerations in which alterations in neurofilament content are an early aspect, and their pathophysiology is assessed in terms of abnormalities of neurofilament synthesis, entry into the axon, transport, and turnover.

Keywords:   axons, cytoskeletal changes, axonal cytoskeleton, Wallerian degeneration, neurofilaments

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