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The AxonStructure, Function and Pathophysiology$
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Stephen G. Waxman, Jeffery D. Kocsis, and Peter K. Stys

Print publication date: 1995

Print ISBN-13: 9780195082937

Published to Oxford Scholarship Online: May 2009

DOI: 10.1093/acprof:oso/9780195082937.001.0001

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PRINTED FROM OXFORD SCHOLARSHIP ONLINE (oxford.universitypressscholarship.com). (c) Copyright Oxford University Press, 2021. All Rights Reserved. An individual user may print out a PDF of a single chapter of a monograph in OSO for personal use. date: 05 March 2021

Anoxic/ischemic injury in axons

Anoxic/ischemic injury in axons

Chapter:
(p.462) 24 Anoxic/ischemic injury in axons
Source:
The Axon
Author(s):

PETER K. STYS

BRUCE R. RANSOM

JOEL A. BLACK

STEPHEN G. WAXMAN

Publisher:
Oxford University Press
DOI:10.1093/acprof:oso/9780195082937.003.0024

Nerve fibers in both the central nervous system and peripheral nervous system must maintain adequate membrane polarization and transmembrane ion gradients to sustain action potential propagation and maintain normal biochemical homeostasis for survival. Maintenance of adequate transmembrane ion gradients is the single most expensive task performed by nerve fibers. Axons are critically dependent on adequate supplies of oxygen and glucose for normal function and survival. Anoxia/ischemia—the pathological state wherein one of both substrates is limited—is a major mechanism of injury in many human diseases involving both central and peripheral axons. This chapter reviews cellular energy metabolism as it relates to axons.

Keywords:   axonal injury, nerve fibers, central nervous system, energy metabolism, peripheral nervous system, biochemical homeostasis

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