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The AxonStructure, Function and Pathophysiology$
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Stephen G. Waxman, Jeffery D. Kocsis, and Peter K. Stys

Print publication date: 1995

Print ISBN-13: 9780195082937

Published to Oxford Scholarship Online: May 2009

DOI: 10.1093/acprof:oso/9780195082937.001.0001

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PRINTED FROM OXFORD SCHOLARSHIP ONLINE (oxford.universitypressscholarship.com). (c) Copyright Oxford University Press, 2021. All Rights Reserved. An individual user may print out a PDF of a single chapter of a monograph in OSO for personal use. date: 21 October 2021

Abnormal excitability in injured axons

Abnormal excitability in injured axons

Chapter:
(p.530) 27 Abnormal excitability in injured axons
Source:
The Axon
Author(s):

MARSHALL DEVOR

Publisher:
Oxford University Press
DOI:10.1093/acprof:oso/9780195082937.003.0027

This chapter discusses the abnormal excitability of injured axons. Injured axons display abnormal hyperexcitability. This is expressed in the form of abnormal sensitivity to a broad range of depolarizing stimuli: physical, chemical, and metabolic. Associated with this hyperexcitability are a number of processes that tend to amplify the abnormal afferent barrage. Prominent among these are different forms of axon-to-axon cross-excitation. The underlying hyperexcitability as well as the specific stimulus sensitivities are the result of remodeling of membrane electrical properties in end-bulbs, sprouts, and patches of demyelination. Of particular importance to this remodeling process is accumulation of Na+ channels in the local axonal membrane.

Keywords:   axons, axon injury, ectopia, hyperexcitability, injured axons, depolarizing stimuli

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