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The AxonStructure, Function and Pathophysiology$
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Stephen G. Waxman, Jeffery D. Kocsis, and Peter K. Stys

Print publication date: 1995

Print ISBN-13: 9780195082937

Published to Oxford Scholarship Online: May 2009

DOI: 10.1093/acprof:oso/9780195082937.001.0001

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Abnormal excitability in injured axons

Abnormal excitability in injured axons

(p.530) 27 Abnormal excitability in injured axons
The Axon


Oxford University Press

This chapter discusses the abnormal excitability of injured axons. Injured axons display abnormal hyperexcitability. This is expressed in the form of abnormal sensitivity to a broad range of depolarizing stimuli: physical, chemical, and metabolic. Associated with this hyperexcitability are a number of processes that tend to amplify the abnormal afferent barrage. Prominent among these are different forms of axon-to-axon cross-excitation. The underlying hyperexcitability as well as the specific stimulus sensitivities are the result of remodeling of membrane electrical properties in end-bulbs, sprouts, and patches of demyelination. Of particular importance to this remodeling process is accumulation of Na+ channels in the local axonal membrane.

Keywords:   axons, axon injury, ectopia, hyperexcitability, injured axons, depolarizing stimuli

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