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The AxonStructure, Function and Pathophysiology$
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Stephen G. Waxman, Jeffery D. Kocsis, and Peter K. Stys

Print publication date: 1995

Print ISBN-13: 9780195082937

Published to Oxford Scholarship Online: May 2009

DOI: 10.1093/acprof:oso/9780195082937.001.0001

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PRINTED FROM OXFORD SCHOLARSHIP ONLINE (oxford.universitypressscholarship.com). (c) Copyright Oxford University Press, 2021. All Rights Reserved. An individual user may print out a PDF of a single chapter of a monograph in OSO for personal use. date: 05 March 2021

Overview of clinical aspects of multiple sclerosis, including cognitive deficit

Overview of clinical aspects of multiple sclerosis, including cognitive deficit

Chapter:
(p.661) 33 Overview of clinical aspects of multiple sclerosis, including cognitive deficit
Source:
The Axon
Author(s):

W. IAN McDONALD

Publisher:
Oxford University Press
DOI:10.1093/acprof:oso/9780195082937.003.0033

One of the most striking characteristics of multiple sclerosis is how complete recovery usually is after quite devastating relapses early in the course of the disease. The lesions nevertheless persist and remain visible by magnetic resonance imaging. This creates a clinicopathological paradox: Extensive pathology often is evident, with but minor clinical deficit. This chapter aims to resolve the clinicopathological paradox by reviewing the present understanding of the pathological and physiological dynamics of multiple sclerosis and how they determine its symptomatology.

Keywords:   multiple sclerosis, pathology, axons, lesions, magnetic resonance imaging

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