- Title Pages
- Dedication
- Preface
- Contributors
- 1 Electrical activity of nerve: The background up to 1952
- 2 Morphology of normal peripheral axons
- 3 Morphology of central nervous system axons
- 4 Physiology of axons
- 5 The Schwann cell: Morphology and development
- 6 The oligodendrocyte, the perinodal astrocyte, and the central node of Ranvier
- 7 Molecular biology of myelination
- 8 Mechanisms of adhesion between axons and glial cells
- 9 Axonal transport: Function and mechanisms
- 10 Development of axons: Calcium, steering, and the growth cone
- 11 Voltage-gated ion channels in axons: Localization, function, and development
- 12 Molecular biology of voltage-dependent potassium and sodium channels
- 13 Voltage-clamp studies in axons: Macroscopic and single-channel currents
- 14 Modulation of axonal excitability by neurotransmitter receptors
- 15 Ion pumps and exchangers
- 16 Mechanisms of accommodation and adaptation in myelinated axons
- 17 Electrophysiological approaches to the study of axons
- 18 Action potential conduction recorded optically in normal, demyelinated, and remyelinating axons
- 19 Reaction of the neuronal cell body to axonal damage
- 20 Axonal degeneration and disorders of the axonal cytoskeleton
- 21 Pathology of demyelinated and dysmyelinated axons
- 22 Pathology of the myelin sheath
- 23 Pathophysiology of demyelinated axons
- 24 Anoxic/ischemic injury in axons
- 25 Traumatic injury of spinal axons
- 26 Diffuse axonal injury
- 27 Abnormal excitability in injured axons
- 28 Regeneration of peripheral nervous system axons
- 29 Role of cellular interactions in axonal growth and regeneration
- 30 Clinical electrophysiology of peripheral nervous system axons
- 31 Clinical assessment of central nervous system axons: Evoked potentials
- 32 Human peripheral nerve disease (peripheral neuropathies)
- 33 Overview of clinical aspects of multiple sclerosis, including cognitive deficit
- 34 Clinical aspects of traumatic injury to central nervous system axons
- Index
The Schwann cell: Morphology and development
The Schwann cell: Morphology and development
- Chapter:
- (p.97) 5 The Schwann cell: Morphology and development
- Source:
- The Axon
- Author(s):
NAOMI KLEITMAN
RICHARD P. BUNGE
- Publisher:
- Oxford University Press
This chapter describes the sequential phenomena observed during the development of the peripheral nerve, with emphasis on the Schwann cell. It presents research elucidating the mechanisms by which these phenomena are controlled. The use of tissue culture models of nerve development is emphasized inasmuch as these have contributed greatly to the understanding of the role of each of the peripheral nerve cell types at each stage of differentiation. The chapter reviews how these studies have elucidated the interactions that create the fully functional nerve. Finally, it discusses ways in which understanding these cellular interactions may be exploited to maximize regeneration in the wake of injury.
Keywords: peripheral nerves, tissue culture models, nerve development, nerve cells, myelination
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- Title Pages
- Dedication
- Preface
- Contributors
- 1 Electrical activity of nerve: The background up to 1952
- 2 Morphology of normal peripheral axons
- 3 Morphology of central nervous system axons
- 4 Physiology of axons
- 5 The Schwann cell: Morphology and development
- 6 The oligodendrocyte, the perinodal astrocyte, and the central node of Ranvier
- 7 Molecular biology of myelination
- 8 Mechanisms of adhesion between axons and glial cells
- 9 Axonal transport: Function and mechanisms
- 10 Development of axons: Calcium, steering, and the growth cone
- 11 Voltage-gated ion channels in axons: Localization, function, and development
- 12 Molecular biology of voltage-dependent potassium and sodium channels
- 13 Voltage-clamp studies in axons: Macroscopic and single-channel currents
- 14 Modulation of axonal excitability by neurotransmitter receptors
- 15 Ion pumps and exchangers
- 16 Mechanisms of accommodation and adaptation in myelinated axons
- 17 Electrophysiological approaches to the study of axons
- 18 Action potential conduction recorded optically in normal, demyelinated, and remyelinating axons
- 19 Reaction of the neuronal cell body to axonal damage
- 20 Axonal degeneration and disorders of the axonal cytoskeleton
- 21 Pathology of demyelinated and dysmyelinated axons
- 22 Pathology of the myelin sheath
- 23 Pathophysiology of demyelinated axons
- 24 Anoxic/ischemic injury in axons
- 25 Traumatic injury of spinal axons
- 26 Diffuse axonal injury
- 27 Abnormal excitability in injured axons
- 28 Regeneration of peripheral nervous system axons
- 29 Role of cellular interactions in axonal growth and regeneration
- 30 Clinical electrophysiology of peripheral nervous system axons
- 31 Clinical assessment of central nervous system axons: Evoked potentials
- 32 Human peripheral nerve disease (peripheral neuropathies)
- 33 Overview of clinical aspects of multiple sclerosis, including cognitive deficit
- 34 Clinical aspects of traumatic injury to central nervous system axons
- Index
