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The AxonStructure, Function and Pathophysiology$
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Stephen G. Waxman, Jeffery D. Kocsis, and Peter K. Stys

Print publication date: 1995

Print ISBN-13: 9780195082937

Published to Oxford Scholarship Online: May 2009

DOI: 10.1093/acprof:oso/9780195082937.001.0001

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PRINTED FROM OXFORD SCHOLARSHIP ONLINE (oxford.universitypressscholarship.com). (c) Copyright Oxford University Press, 2021. All Rights Reserved. An individual user may print out a PDF of a single chapter of a monograph in OSO for personal use. date: 05 March 2021

Mechanisms of adhesion between axons and glial cells

Mechanisms of adhesion between axons and glial cells

Chapter:
(p.164) 8 Mechanisms of adhesion between axons and glial cells
Source:
The Axon
Author(s):

JAMES L. SALZER

Publisher:
Oxford University Press
DOI:10.1093/acprof:oso/9780195082937.003.0008

This chapter discusses the structural features of cell adhesion molecules (CAMs) and their role in axonal-glial interactions of myelination and nerve fiber outgrowth. CAMs mediate many of the morphogenetic events that occur during nerve fiber outgrowth, ensheathment, and myelination. Dramatic changes in the expression of these molecules accompany and are likely to underlie these complex developmental processes. The molecular mechanisms by which these molecules regulate these events probably involve reorganization of the cytoskeleton and intracellular signaling events, but they remain little understood.

Keywords:   cell adhesion molecules, axonal-glial interactions, myelination, nerve fiber outgrowth, cytoskeleton, intracellular signaling events

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