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Molecular and Cellular Approaches to Neural Development$
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W. Maxwell Cowan, Thomas M. Jessell, and S. Lawrence Zipursky

Print publication date: 1998

Print ISBN-13: 9780195111668

Published to Oxford Scholarship Online: May 2009

DOI: 10.1093/acprof:oso/9780195111668.001.0001

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Neural induction in Xenopus

Neural induction in Xenopus

(p.1) 1 Neural induction in Xenopus
Molecular and Cellular Approaches to Neural Development

Richard M. Harland

Oxford University Press

This chapter discusses the biology of neural induction in Xenopus laevis. Recently, several diverse mechanisms that have been proposed to account for neural induction have been simplified into one. Evidence supporting the proposed mechanism—which hinges on the function of the bone morphogenetic protein family (BMP)—is reviewed. Signalling by BMPs biases ectoderm toward an epidermal fate. BMP mRNAs are presented in the ectoderm, and blockage of their function by cell dissociation, use of dominant negative BMP receptors, or dominant negative BMP ligands results in neural development.

Keywords:   Xenopus laevis, bone morphogenetic protein, neural induction, ectoderm, cell dissociation

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