This chapter reviews recent studies that suggest that it is no longer tenable to consider glial cells as passive support cells. These studies have shown that interactions between neurons and glial cells control neurogenesis, myelination, node of Ranvier formation, synapse formation, and maybe even neuronal signaling. It is argued that the development, structure, and function of the brain all depend on an intimate neuron-glia partnership. A full understanding of nearly all neurobiological processes must include consideration of the role of glial cells.
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