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Molecular and Cellular Approaches to Neural Development$
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W. Maxwell Cowan, Thomas M. Jessell, and S. Lawrence Zipursky

Print publication date: 1998

Print ISBN-13: 9780195111668

Published to Oxford Scholarship Online: May 2009

DOI: 10.1093/acprof:oso/9780195111668.001.0001

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PRINTED FROM OXFORD SCHOLARSHIP ONLINE (oxford.universitypressscholarship.com). (c) Copyright Oxford University Press, 2022. All Rights Reserved. An individual user may print out a PDF of a single chapter of a monograph in OSO for personal use.date: 07 July 2022

Neurotrophic factors and their receptors

Neurotrophic factors and their receptors

Roles in neuronal development and function

(p.220) 6 Neurotrophic factors and their receptors
Molecular and Cellular Approaches to Neural Development

Louis F. Reichardt

Fariñas Isabel

Oxford University Press

Neurotrophic factors are important regulators of the development and maintenance of vertebrate nervous system. During the development of the nervous system, neuronal populations undergo a process of naturally occurring cell death at a time when their axons are innervating target areas. This mechanism ensures a balance between the size of an innervating population and the size of its target territory. Nerve growth factor (NGF) was the first neurotrophic factor to be discovered. More recent work has shown that other molecules are secreted by target organs that regulate neuronal survival and differentiation. This chapter focuses on neurotrophins with brief descriptions of the actions of these other molecules.

Keywords:   neurotrophins, nerve growth factor, nervous system development, neuronal populations, cell death, neurotrophic factor

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