Jump to ContentJump to Main Navigation
Issues in Palliative Care Research$
Users without a subscription are not able to see the full content.

Russell K. Portenoy and Eduardo Bruera

Print publication date: 2003

Print ISBN-13: 9780195130652

Published to Oxford Scholarship Online: November 2011

DOI: 10.1093/acprof:oso/9780195130652.001.0001

Show Summary Details
Page of

PRINTED FROM OXFORD SCHOLARSHIP ONLINE (oxford.universitypressscholarship.com). (c) Copyright Oxford University Press, 2020. All Rights Reserved. An individual user may print out a PDF of a single chapter of a monograph in OSO for personal use. date: 24 October 2020

Methodological Issues in the Design of Analgesic Clinical Trials

Methodological Issues in the Design of Analgesic Clinical Trials

(p.3) 1 Methodological Issues in the Design of Analgesic Clinical Trials
Issues in Palliative Care Research

Russell K. Portenoy

Eduardo Bruera

Oxford University Press

This chapter discusses some of the firm conclusions from the experience of analgesic research and highlights areas of analgesic trial methodology that have had relatively little exploration, particularly repeated-dose studies in chronic pain, where an ongoing dialogue among symptom researchers might move all of these fields ahead. Several generations of analgesic researchers have come to a consensus on approaches to single-dose analgesic studies. Because the studies of other symptoms may share some of the same challenges, palliative care researchers may benefit from a familiarity with the analgesic study design literature. However, many clinical research problems with pain and other symptoms have received rather little study, including optimizing the sensitivity of symptom-based measures, combination studies, and the choice of control groups in repeated-dose studies. The solution to many of these problems may be facilitated by frequent discussions among clinical researchers working in different symptom areas.

Keywords:   analgesic research, chronic pain, palliative care, symptom researchers, combination studies, repeated-dose studies

Oxford Scholarship Online requires a subscription or purchase to access the full text of books within the service. Public users can however freely search the site and view the abstracts and keywords for each book and chapter.

Please, subscribe or login to access full text content.

If you think you should have access to this title, please contact your librarian.

To troubleshoot, please check our FAQs , and if you can't find the answer there, please contact us .