Jump to ContentJump to Main Navigation
Cancer Epidemiology and Prevention$
Users without a subscription are not able to see the full content.

David Schottenfeld and Joseph F. Fraumeni

Print publication date: 2006

Print ISBN-13: 9780195149616

Published to Oxford Scholarship Online: September 2009

DOI: 10.1093/acprof:oso/9780195149616.001.0001

Show Summary Details
Page of

PRINTED FROM OXFORD SCHOLARSHIP ONLINE (oxford.universitypressscholarship.com). (c) Copyright Oxford University Press, 2021. All Rights Reserved. An individual user may print out a PDF of a single chapter of a monograph in OSO for personal use. date: 16 April 2021

Molecular and Genetic Events in Neoplastic Transformation

Molecular and Genetic Events in Neoplastic Transformation

(p.47) 4 Molecular and Genetic Events in Neoplastic Transformation
Cancer Epidemiology and Prevention



Oxford University Press

This chapter illustrates some of the basic molecular and genetic mechanisms that underlie the development of cancer. The chapter is organized into four main sections. The first section examines perspectives on the roles of oncogenes, tumor suppressor genes, and genomic instability genes in the pathogenesis of malignancy. The second section presents the genetic and epigenetic alterations that disrupt normal function of cancer genes. The third section discusses the alteration of cell cycle progression and checkpoint mechanisms relative to their possible contribution to carcinogenesis. The last section summarizes the phenotypic characteristics of cancer cells, including proliferation, apoptosis, angiogenesis, and metastasis as related to specific molecular events.

Keywords:   cancer development, cancer genes, cancer cells, oncogenes, tumor suppressor genes, genomic instability, malignancy

Oxford Scholarship Online requires a subscription or purchase to access the full text of books within the service. Public users can however freely search the site and view the abstracts and keywords for each book and chapter.

Please, subscribe or login to access full text content.

If you think you should have access to this title, please contact your librarian.

To troubleshoot, please check our FAQs , and if you can't find the answer there, please contact us .