Excitatory Amino Acid Transmission in Health and Disease
Robert Balazs, Richard J. Bridges, and Carl W. Cotman
Abstract
This book provides a comprehensive, easy-to-read survey of excitatory amino acids and synaptic transmission. It begins with descriptions of the structure, function, and pharmacology of both the ionotropic and the metabotropic glutamate receptors and the glutamate transporters. Subsequent chapters deal with molecular aspects of the regulation of glutamatergic transmission, including receptor trafficking, the role of glutamate transport, the unique molecular architecture of the synapses (post-synaptic density), and the signal transduction pathways mediated by glutamate. Also unique to the book i ... More
This book provides a comprehensive, easy-to-read survey of excitatory amino acids and synaptic transmission. It begins with descriptions of the structure, function, and pharmacology of both the ionotropic and the metabotropic glutamate receptors and the glutamate transporters. Subsequent chapters deal with molecular aspects of the regulation of glutamatergic transmission, including receptor trafficking, the role of glutamate transport, the unique molecular architecture of the synapses (post-synaptic density), and the signal transduction pathways mediated by glutamate. Also unique to the book is a chapter on synaptic plasticity that covers long-term potentiation and long-term depression in relationship to synaptic function. It is striking that glutamate is implicated in most of the major neurological diseases, such as stroke, Alzheimer's disease, and schizophrenia.
Keywords:
amino acids,
synaptic transmission,
glutamate receptors,
glutamate transporters,
neurological diseases,
synapses,
synaptic plasticity,
long-term potentiation,
long-term depression
Bibliographic Information
| Print publication date: 2005 |
Print ISBN-13: 9780195150025 |
| Published to Oxford Scholarship Online: January 2010 |
DOI:10.1093/acprof:oso/9780195150025.001.0001 |
Authors
Affiliations are at time of print publication.
Robert Balazs, author
University of California at Irvine
Richard J. Bridges, author
University of Montana
Carl W. Cotman, author
University of California at Irvine
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