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Neuroglia

Helmut Kettenmann and Bruce R. Ransom

Abstract

This book details the basic biology and function of glial cells. It covers the entire field of glial research from the basic molecular and cellular properties of these cells to their involvement in neurological diseases including stroke, Alzheimer's Disease, and multiple sclerosis. This edition includes new chapters on transmitter release by extocytosis from glia, glia derived stem cells, glia synaptic transmission, glia and axon guidance, an entirely new section on mechanisms of glial injury, and several new chapters on the roles of glia in different diseases. It covers the fields of neuroana ... More

Keywords: glial cells, glial research, molecular properties, cellular properties, stroke, Alzheimer's Disease, multiple sclerosis, extocytosis, stem cells, synaptic transmission

Bibliographic Information

Print publication date: 2004 Print ISBN-13: 9780195152227
Published to Oxford Scholarship Online: May 2009 DOI:10.1093/acprof:oso/9780195152227.001.0001

Authors

Affiliations are at time of print publication.

Helmut Kettenmann, editor
Head of the Research Unit in Cellular Neurosciences, Max-Delbrück-Center for Molecular Medicine, Berlin, Germany and Professor of Neurobiology at the Charité, Humboldt University, Berlin, Germany

Bruce R. Ransom, editor
Warren Magnuson Professor and Chair, Department of Neurology, Professor of Neurology, and of Physiology and Biophysics, University of Washington, Seattle, USA

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Contents

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Front Matter

Title Pages

Dedication

Preface to the second edition

Preface to the first edition

Contributors

1 The Concept of Neuroglia: A Historical Perspective

I PROPERTIES OF NEUROGLIAL CELLS

2 Astrocytes and Ependymal Glia

Andreas Reichenbach, and Hartwig Wolburg

3 Structure and Function of Oligodendrocytes

Arthur M. Butt

4 Schwann Cells and Myelin

Rudolf Martini

5 Microglial Cells

Wolfgang J. Streit

6 Lineages of Astrocytes and Oligodendrocytes

James E. Goldman

7 The Schwann Cell Lineage

Kristján R. Jessen, and Rhona Mirsky

8 The Role of Neurogenic Astroglial Cells in the Developing and Adult Central Nervous System

Stephen C. Noctor, Lidija Ivic, Verónica Martínez-Cerdeño, and Arnold R. Kriegstein

9 Voltage-Activated Ion Channels in Glial Cells

Michelle L. Olsen, and Harald W. Sontheimer

10 Receptors for Neurotransmitters and Hormones

Helmut Kettenmann, and Christian Steinhäuser

11 Cytokine and Chemokine Receptors and Signaling

Duane R. Wesemann, and Etty N. Benveniste

12 Mechanisms of Solute Transport in Glia

Neville Brookes

13 Gap Junctions and Hemichannels

Bruce R. Ransom, and Zu-Cheng Ye

14 Quantal Release of Transmitter: Not Only from Neurons but from Aastrocytes as Well?

Andrea Volterra, and Jacopo Meldolesi

15 Enzymes of Carbohydrate and Energy Metabolism

Bernd Hamprecht, Stephan Verleysdonk, and Heinrich Wiesinger

16 Second Messenger Systems

Sean Murphy, and Brian R. Pearce

17 Intracellular Calcium Control Mechanisms in Glia

Maria Luisa Cotrina, and Maiken Nedergaard

18 Cytoskeletal Proteins in Astroglia

Lawrence F. Eng, and Yuen Ling Lee

II FUNCTIONS OF NEUROGLIAL CELLS

19 Molecular Biology of Myelination

Anthony T. Campagnoni

20 Factors Controlling Myelin Formation

Lynn D. Hudson

21 Myelin Function and Saltatory Conduction

Stephen G. Waxman, and Lakshmi Bangalore

22 Cytokine Production

Francesca Aloisi

23 Interaction of Glial Cells with Monocytes

Ingo Bechmann, and Robert Nitsch

24 Antigen Processing, Presentation, and T Cell Interaction

Harald Neumann

25 The Role of Glia in the Formation and Function of the Blood–Brain Barrier

Hannelore Bauer, Hans-Christian Bauer, Reiner F. Haseloff, and Ingolf E. Blasig

26 Extracellular Potassium and pH: Homeostasis and Signaling

Jonathan A. Coles, and Joachim W. Deitmer

27 Astrocyte Neurotransmitter Uptake

Raymond A. Swanson

28 Glia and Synaptic Transmission

Eric A. Newman

29 The Central Role of Astrocytes in Neuroenergetics

Luc Pellerin, and Pierre J. Magistretti

30 Growth Factors for Neurons Provided by Macroglial Cells

Bernhard Reuss, and Klaus Unsicker

31 Radial Glial Cells: Scaffolding for Cortical Development and Evolution

Pasko Rakic

32 Axon Guidance

Andreas Faissner

III DISEASE AND NEUROGLIAL CELLS

33 Astrocyte Injury

Christopher J. Feeney, and Peter K. Stys

34 Oligodendrocyte and Schwann Cell Injury

Jennifer K. Ness, and Mark P. Goldberg

35 Response of Microglia to Brain Injury

Kazuyuki Nakajima, and Shinichi Kohsaka

36 Axonal Regeneration in the Peripheral Nervous System of Mammals

Olawale A.R. Sulaiman, J. Gordon Boyd, and Tessa Gordon

37 Axonal Regeneration in the Central Nervous System of Mammals

Isabel Klusman, and Martin E. Schwab

38 Transplantation of Myelin-Forming Cells

William F. Blakemore, and Robin J.M. Franklin

39 Multiple Sclerosis

Jack Antel, and Douglas Arnold

40 Human Immunodeficiency Virus Infection of the Central Nervous System

Elena Ryzhova, Dennis L. Kolson, and Francisco González-Scarano

41 Focal Cerebral Ischemia: The Multifaceted Role of Glial Cells

Ulrich Dirnagl, and Josef Priller

42 Gliomas

Michael Weller

43 Neurological Mouse Mutants: A Molecular-Genetic Analysis of Myelin Proteins

Klaus-Armin Nave, and Ueli Suter

44 Astrocytic Swelling in Neuropathology

Alexander A. Mongin, and Harold K. Kimelberg

45 The Activation of Microglia as an Early Sign of Disease Progression in Alzheimer's Disease

Robert Veerhuis, Jeroen J.M. Hoozemans, Annachiara Cagnin, Piet Eikelenboom, and Richard B. Banati

46 Peripheral Neuropathy and the Schwann Cell

Rita M. Cowell, and James W. Russell

47 Reaction of Glial Cells in Infectious Disorders of the Central Nervous System

Martina Deckert, and Dirk Schlüter

End Matter

Index