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Neuroglia$
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Helmut Kettenmann and Bruce R. Ransom

Print publication date: 2004

Print ISBN-13: 9780195152227

Published to Oxford Scholarship Online: May 2009

DOI: 10.1093/acprof:oso/9780195152227.001.0001

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PRINTED FROM OXFORD SCHOLARSHIP ONLINE (oxford.universitypressscholarship.com). (c) Copyright Oxford University Press, 2021. All Rights Reserved. An individual user may print out a PDF of a single chapter of a monograph in OSO for personal use. date: 05 March 2021

Astrocyte Injury

Astrocyte Injury

Chapter:
(p.421) 33 Astrocyte Injury
Source:
Neuroglia
Author(s):

Christopher J. Feeney

Peter K. Stys

Publisher:
Oxford University Press
DOI:10.1093/acprof:oso/9780195152227.003.0033

A general perception has emerged over the past two decades of research that astrocytes are relatively resistant to insults such as those caused by ischemia [oxygen/glucose deprivation (OGD)], and oxidative stress [e.g., reactive oxygen species (ROS)] damage. Recent work, however, points to significant astrocyte dysfunction in response to these injuries. This chapter focuses on the responses of astrocytes to hypoxia/ischemia and trauma. It argues that given the importance of astrocyte functioning to the microenvironment of the central nervous system (CNS), it is apparent that alterations in their physiology during pathological states (such as ischemia and traumatic brain injury) could have profound implications for the progression of these insults.

Keywords:   astrocytes, hypoxia, ischemia, trauma, stroke, central nervous system

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