Jump to ContentJump to Main Navigation
Users without a subscription are not able to see the full content.

Helmut Kettenmann and Bruce R. Ransom

Print publication date: 2004

Print ISBN-13: 9780195152227

Published to Oxford Scholarship Online: May 2009

DOI: 10.1093/acprof:oso/9780195152227.001.0001

Show Summary Details
Page of

PRINTED FROM OXFORD SCHOLARSHIP ONLINE (oxford.universitypressscholarship.com). (c) Copyright Oxford University Press, 2021. All Rights Reserved. An individual user may print out a PDF of a single chapter of a monograph in OSO for personal use. date: 05 March 2021

Astrocyte Injury

Astrocyte Injury

(p.421) 33 Astrocyte Injury

Christopher J. Feeney

Peter K. Stys

Oxford University Press

A general perception has emerged over the past two decades of research that astrocytes are relatively resistant to insults such as those caused by ischemia [oxygen/glucose deprivation (OGD)], and oxidative stress [e.g., reactive oxygen species (ROS)] damage. Recent work, however, points to significant astrocyte dysfunction in response to these injuries. This chapter focuses on the responses of astrocytes to hypoxia/ischemia and trauma. It argues that given the importance of astrocyte functioning to the microenvironment of the central nervous system (CNS), it is apparent that alterations in their physiology during pathological states (such as ischemia and traumatic brain injury) could have profound implications for the progression of these insults.

Keywords:   astrocytes, hypoxia, ischemia, trauma, stroke, central nervous system

Oxford Scholarship Online requires a subscription or purchase to access the full text of books within the service. Public users can however freely search the site and view the abstracts and keywords for each book and chapter.

Please, subscribe or login to access full text content.

If you think you should have access to this title, please contact your librarian.

To troubleshoot, please check our FAQs , and if you can't find the answer there, please contact us .