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Biology of Aggression$
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Randy J. Nelson

Print publication date: 2005

Print ISBN-13: 9780195168761

Published to Oxford Scholarship Online: May 2009

DOI: 10.1093/acprof:oso/9780195168761.001.0001

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PRINTED FROM OXFORD SCHOLARSHIP ONLINE (oxford.universitypressscholarship.com). (c) Copyright Oxford University Press, 2021. All Rights Reserved. An individual user may print out a PDF of a single chapter of a monograph in OSO for personal use. date: 18 October 2021

Brain Serotonin and Aggressive Disposition in Humans and Nonhuman Primates

Brain Serotonin and Aggressive Disposition in Humans and Nonhuman Primates

(p.65) 4 Brain Serotonin and Aggressive Disposition in Humans and Nonhuman Primates
Biology of Aggression

Stephen B. Manuck

Jay R. Kaplan

Francis E. Lotrich

Oxford University Press

This chapter begins with a brief introduction to the neurobiology of serotonin, including common methods of investigation and sources of serotonin-associated genetic variation. It briefly addresses comparative conceptualizations of aggressive behavior in nonhuman primates and people, including the role of antagonistic interaction in primate social dominance and human psychopathology. It summarizes the substantial literature on CNS serotonergic activity as a correlate of aggressive disposition, as seen in studies employing neurochemical indices of serotonergic function, neuropharmacologic challenges, functional neuroimaging, and neurogenetic methodologies. Finally, the chapter attempts to integrate observations derived from studies on monkeys and humans, identify implications of these findings for models of serotonergic influences on aggression, and speculate briefly regarding possible evolutionary origins of these associations.

Keywords:   neurochemistry, aggression, serotonergic activity, primates, neuroimaging, antagonistic interaction

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