- Title Pages
- Acknowledgments
- List of Abbreviations
- Contributors
- 1 Models of Neurotoxicity Provide Unique Insight into Normal Development
- 2 Cell Proliferation
- 3 Neuronal Migration
- 4 Neuronal Differentiation: From Axons to Synapses
- 5 Cell Death
- 6 Intracellular Pathways of Neuronal Death
- 7 Developmental Disorders and Evolutionary Expectations: Mechanisms of Resilience
- 8 Prenatal Alcohol Exposure and Human Development
- 9 Influence of Alcohol on Structure of the Developing Human Brain
- 10 Prenatal Ethanol Exposure and Fetal Programming: Implications for Endocrine and Immune Development and Long-Term Health
- 11 Early Exposure to Ethanol Affects the Proliferation of Neuronal Precursors
- 12 Effects of Ethanol on the Regulation of Cell Cycle in Neural Stem Cells
- 13 Mechanisms of Ethanol-Induced Alterations in Neuronal Migration
- 14 Effects of Ethanol on Mechanisms Regulating Neuronal Process Outgrowth
- 15 Neuronal Survival is Compromised by Ethanol: Extracellular Mediators
- 16 Intracellular Events in Ethanol-induced Neuronal Death
- 17 Neural Crest and Developmental Exposure to Ethanol
- 18 Glial Targets of Developmental Exposure to Ethanol
- 19 Tobacco Use During Pregnancy: Epidemiology and Effects on Offspring
- 20 Prenatal Nicotine Exposure and Animal Behavior
- 21 Neuronal Receptors for Nicotine: Functional Diversity and Developmental Changes
- 22 Neural Precursors as Preferential Targets for Drug Abuse: Long-Term Consequences and Latent Susceptibility to Central Nervous System Disorders
- 23 Nicotinic Receptor Regulation of Developing Catecholamine Systems
- Index
Cell Proliferation
Cell Proliferation
- Chapter:
- (p.9) 2 Cell Proliferation
- Source:
- Brain Development
- Author(s):
Bernhard Suter
Pradeep G. Bhide
- Publisher:
- Oxford University Press
Cell proliferation is the earliest step in the protracted process of mammalian brain development. Various genetic and environmental factors modulate the pace of cell proliferation and the number and type of cells produced. This chapter describes the spatiotemporal features of cell proliferation and the effect of neurotransmitters, major constituents of the chemical environment of the developing brain that modulate the process of precursor cell formation. It focuses on three neurotransmitters that are the most abundant in the developing brain: dopamine, γ-aminobutyric acid (GABA), and glutamate. The goal is to present an overview of the organization and activity of precursor cell populations and discuss the potential for modulation of precursor cell activity by neurotransmitters.
Keywords: cell proliferation, precursor cells, neurotransmitters
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- Title Pages
- Acknowledgments
- List of Abbreviations
- Contributors
- 1 Models of Neurotoxicity Provide Unique Insight into Normal Development
- 2 Cell Proliferation
- 3 Neuronal Migration
- 4 Neuronal Differentiation: From Axons to Synapses
- 5 Cell Death
- 6 Intracellular Pathways of Neuronal Death
- 7 Developmental Disorders and Evolutionary Expectations: Mechanisms of Resilience
- 8 Prenatal Alcohol Exposure and Human Development
- 9 Influence of Alcohol on Structure of the Developing Human Brain
- 10 Prenatal Ethanol Exposure and Fetal Programming: Implications for Endocrine and Immune Development and Long-Term Health
- 11 Early Exposure to Ethanol Affects the Proliferation of Neuronal Precursors
- 12 Effects of Ethanol on the Regulation of Cell Cycle in Neural Stem Cells
- 13 Mechanisms of Ethanol-Induced Alterations in Neuronal Migration
- 14 Effects of Ethanol on Mechanisms Regulating Neuronal Process Outgrowth
- 15 Neuronal Survival is Compromised by Ethanol: Extracellular Mediators
- 16 Intracellular Events in Ethanol-induced Neuronal Death
- 17 Neural Crest and Developmental Exposure to Ethanol
- 18 Glial Targets of Developmental Exposure to Ethanol
- 19 Tobacco Use During Pregnancy: Epidemiology and Effects on Offspring
- 20 Prenatal Nicotine Exposure and Animal Behavior
- 21 Neuronal Receptors for Nicotine: Functional Diversity and Developmental Changes
- 22 Neural Precursors as Preferential Targets for Drug Abuse: Long-Term Consequences and Latent Susceptibility to Central Nervous System Disorders
- 23 Nicotinic Receptor Regulation of Developing Catecholamine Systems
- Index
