- Title Pages
- Acknowledgments
- List of Abbreviations
- Contributors
- 1 Models of Neurotoxicity Provide Unique Insight into Normal Development
- 2 Cell Proliferation
- 3 Neuronal Migration
- 4 Neuronal Differentiation: From Axons to Synapses
- 5 Cell Death
- 6 Intracellular Pathways of Neuronal Death
- 7 Developmental Disorders and Evolutionary Expectations: Mechanisms of Resilience
- 8 Prenatal Alcohol Exposure and Human Development
- 9 Influence of Alcohol on Structure of the Developing Human Brain
- 10 Prenatal Ethanol Exposure and Fetal Programming: Implications for Endocrine and Immune Development and Long-Term Health
- 11 Early Exposure to Ethanol Affects the Proliferation of Neuronal Precursors
- 12 Effects of Ethanol on the Regulation of Cell Cycle in Neural Stem Cells
- 13 Mechanisms of Ethanol-Induced Alterations in Neuronal Migration
- 14 Effects of Ethanol on Mechanisms Regulating Neuronal Process Outgrowth
- 15 Neuronal Survival is Compromised by Ethanol: Extracellular Mediators
- 16 Intracellular Events in Ethanol-induced Neuronal Death
- 17 Neural Crest and Developmental Exposure to Ethanol
- 18 Glial Targets of Developmental Exposure to Ethanol
- 19 Tobacco Use During Pregnancy: Epidemiology and Effects on Offspring
- 20 Prenatal Nicotine Exposure and Animal Behavior
- 21 Neuronal Receptors for Nicotine: Functional Diversity and Developmental Changes
- 22 Neural Precursors as Preferential Targets for Drug Abuse: Long-Term Consequences and Latent Susceptibility to Central Nervous System Disorders
- 23 Nicotinic Receptor Regulation of Developing Catecholamine Systems
- Index
Neural Precursors as Preferential Targets for Drug Abuse: Long-Term Consequences and Latent Susceptibility to Central Nervous System Disorders
Neural Precursors as Preferential Targets for Drug Abuse: Long-Term Consequences and Latent Susceptibility to Central Nervous System Disorders
- Chapter:
- (p.363) 22 Neural Precursors as Preferential Targets for Drug Abuse: Long-Term Consequences and Latent Susceptibility to Central Nervous System Disorders
- Source:
- Brain Development
- Author(s):
Kurt F. Hauser
Nazira El-Hage
Shreya Buch
Gregory N. Barnes
Henrietta S. Bada
James R. Pauly
- Publisher:
- Oxford University Press
Considerable evidence suggests that drugs with abuse liability disrupt development by affecting the production of new neurons and glia. The effects of drug abuse are not limited to a particular cell type, germinal zone, or stage of development, but rather uniquely affect individual neuronal and glial precursor types with various germinal zones. Germinal zones are targeted to varying degrees by most substance with abuse liability. This chapter discusses the effects of opiates and nicotine on the genesis of neural cells.
Keywords: drug abuse, development, neurons, opiates, germinal zone
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- Title Pages
- Acknowledgments
- List of Abbreviations
- Contributors
- 1 Models of Neurotoxicity Provide Unique Insight into Normal Development
- 2 Cell Proliferation
- 3 Neuronal Migration
- 4 Neuronal Differentiation: From Axons to Synapses
- 5 Cell Death
- 6 Intracellular Pathways of Neuronal Death
- 7 Developmental Disorders and Evolutionary Expectations: Mechanisms of Resilience
- 8 Prenatal Alcohol Exposure and Human Development
- 9 Influence of Alcohol on Structure of the Developing Human Brain
- 10 Prenatal Ethanol Exposure and Fetal Programming: Implications for Endocrine and Immune Development and Long-Term Health
- 11 Early Exposure to Ethanol Affects the Proliferation of Neuronal Precursors
- 12 Effects of Ethanol on the Regulation of Cell Cycle in Neural Stem Cells
- 13 Mechanisms of Ethanol-Induced Alterations in Neuronal Migration
- 14 Effects of Ethanol on Mechanisms Regulating Neuronal Process Outgrowth
- 15 Neuronal Survival is Compromised by Ethanol: Extracellular Mediators
- 16 Intracellular Events in Ethanol-induced Neuronal Death
- 17 Neural Crest and Developmental Exposure to Ethanol
- 18 Glial Targets of Developmental Exposure to Ethanol
- 19 Tobacco Use During Pregnancy: Epidemiology and Effects on Offspring
- 20 Prenatal Nicotine Exposure and Animal Behavior
- 21 Neuronal Receptors for Nicotine: Functional Diversity and Developmental Changes
- 22 Neural Precursors as Preferential Targets for Drug Abuse: Long-Term Consequences and Latent Susceptibility to Central Nervous System Disorders
- 23 Nicotinic Receptor Regulation of Developing Catecholamine Systems
- Index
