- Title Pages
- Acknowledgments
- List of Abbreviations
- Contributors
- 1 Models of Neurotoxicity Provide Unique Insight into Normal Development
- 2 Cell Proliferation
- 3 Neuronal Migration
- 4 Neuronal Differentiation: From Axons to Synapses
- 5 Cell Death
- 6 Intracellular Pathways of Neuronal Death
- 7 Developmental Disorders and Evolutionary Expectations: Mechanisms of Resilience
- 8 Prenatal Alcohol Exposure and Human Development
- 9 Influence of Alcohol on Structure of the Developing Human Brain
- 10 Prenatal Ethanol Exposure and Fetal Programming: Implications for Endocrine and Immune Development and Long-Term Health
- 11 Early Exposure to Ethanol Affects the Proliferation of Neuronal Precursors
- 12 Effects of Ethanol on the Regulation of Cell Cycle in Neural Stem Cells
- 13 Mechanisms of Ethanol-Induced Alterations in Neuronal Migration
- 14 Effects of Ethanol on Mechanisms Regulating Neuronal Process Outgrowth
- 15 Neuronal Survival is Compromised by Ethanol: Extracellular Mediators
- 16 Intracellular Events in Ethanol-induced Neuronal Death
- 17 Neural Crest and Developmental Exposure to Ethanol
- 18 Glial Targets of Developmental Exposure to Ethanol
- 19 Tobacco Use During Pregnancy: Epidemiology and Effects on Offspring
- 20 Prenatal Nicotine Exposure and Animal Behavior
- 21 Neuronal Receptors for Nicotine: Functional Diversity and Developmental Changes
- 22 Neural Precursors as Preferential Targets for Drug Abuse: Long-Term Consequences and Latent Susceptibility to Central Nervous System Disorders
- 23 Nicotinic Receptor Regulation of Developing Catecholamine Systems
- Index
Nicotinic Receptor Regulation of Developing Catecholamine Systems
Nicotinic Receptor Regulation of Developing Catecholamine Systems
- Chapter:
- (p.381) 23 Nicotinic Receptor Regulation of Developing Catecholamine Systems
- Source:
- Brain Development
- Author(s):
Frances M. Leslie
Layla Azam
Kathy Gallardo
Kathryn O’Leary
Ryan Franke
Shahrdad Lotfipour
- Publisher:
- Oxford University Press
Nicotine binds to specific cholinergic receptors. A nicotinic acetylcholine receptor (nAChR) is a ligand-gated cation channel. Each receptor consists of five subunit proteins surrounding a channel pore that mediate many of the biological effects of acetylcholine. This chapter uses a combination of biochemical, anatomical, and behavioral approaches to evaluate the hypothesis that functional nAChRs are expressed on catecholamine neurons during critical phases of brain development.
Keywords: nicotinic acetylcholine receptors, neurons, catecholamine neurons
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- Title Pages
- Acknowledgments
- List of Abbreviations
- Contributors
- 1 Models of Neurotoxicity Provide Unique Insight into Normal Development
- 2 Cell Proliferation
- 3 Neuronal Migration
- 4 Neuronal Differentiation: From Axons to Synapses
- 5 Cell Death
- 6 Intracellular Pathways of Neuronal Death
- 7 Developmental Disorders and Evolutionary Expectations: Mechanisms of Resilience
- 8 Prenatal Alcohol Exposure and Human Development
- 9 Influence of Alcohol on Structure of the Developing Human Brain
- 10 Prenatal Ethanol Exposure and Fetal Programming: Implications for Endocrine and Immune Development and Long-Term Health
- 11 Early Exposure to Ethanol Affects the Proliferation of Neuronal Precursors
- 12 Effects of Ethanol on the Regulation of Cell Cycle in Neural Stem Cells
- 13 Mechanisms of Ethanol-Induced Alterations in Neuronal Migration
- 14 Effects of Ethanol on Mechanisms Regulating Neuronal Process Outgrowth
- 15 Neuronal Survival is Compromised by Ethanol: Extracellular Mediators
- 16 Intracellular Events in Ethanol-induced Neuronal Death
- 17 Neural Crest and Developmental Exposure to Ethanol
- 18 Glial Targets of Developmental Exposure to Ethanol
- 19 Tobacco Use During Pregnancy: Epidemiology and Effects on Offspring
- 20 Prenatal Nicotine Exposure and Animal Behavior
- 21 Neuronal Receptors for Nicotine: Functional Diversity and Developmental Changes
- 22 Neural Precursors as Preferential Targets for Drug Abuse: Long-Term Consequences and Latent Susceptibility to Central Nervous System Disorders
- 23 Nicotinic Receptor Regulation of Developing Catecholamine Systems
- Index
