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The Case-Control MethodDesign and Applications$
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Haroutune Armenian

Print publication date: 2009

Print ISBN-13: 9780195187113

Published to Oxford Scholarship Online: September 2009

DOI: 10.1093/acprof:oso/9780195187113.001.0001

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Applications: Evaluation

Applications: Evaluation

The Case-Control Method

Haroutune K. Armenian

Oxford University Press

This chapter begins by describing various approaches to evaluation and situations where one needs to have alternatives for randomized trials in assessing interventions. It then identifies the circumstances that will benefit from the use of the case-control method as an approach for evaluation. Examples of such circumstances include assessment of effectiveness of drugs and their adverse reactions, public health programs, quality of care evaluation, and screening programs. The example of the use of the case-control method to evaluate vaccination programs is presented to illustrate methodological implications of assessing effectiveness and efficacy. The final section of the chapter provides three examples of the application of the case-control studies in evaluation from Tanzania, Brazil, and Nepal.

Keywords:   evaluation, effectiveness, efficacy, drugs, vaccines, screening programs, adverse drug reactions

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