- Title Pages
- Preface
- Introduction
-
Chapter 1 The Developing Brain and Adolescent-Typical Behavior Patterns -
Chapter 2 Competence, Resilience, and Development in Adolescence -
Chapter 3 Mapping Adolescent Brain Maturation Using Structural Magnetic Resonance Imaging -
Chapter 4 The Metamorphosis -
Chapter 5 Transcriptional Regulation in Schizophrenia -
Chapter 6 Stress Effects on the Developing Brain -
Chapter 7 Maternal Programming of Defensive Responses Through Sustained Effects on Gene Expression -
Chapter 8 Neuropeptides and the Development of Social Behaviors -
Chapter 9 The Effects of Early Deprivation on Brain-Behavioral Development -
Chapter 10 Social Stress, Affect, and Neural Function in Adolescence -
Chapter 11 Stress-Induced Pathophysiology Within the Schizophrenia Patient Brain -
Chapter 12 Neurohormones, Neurodevelopment, and the Prodrome of Psychosis in Adolescence -
Chapter 13 The Adolescent Surge in Depression and Emergence of Gender Differences -
Chapter 14 Early Identification and Prevention of Early-Onset Bipolar Disorder -
Chapter 15 Resilience and Vulnerability to Trauma -
Chapter 16 The Developing Adolescent Brain in Socioeconomic Context -
Chapter 17 Brain Development as a Vulnerability Factor in the Etiology of Substance Abuse and Addiction -
Chapter 18 Modifying Brain Networks Underlying Self-Regulation -
Chapter 19 The BrainWise Curriculum -
Chapter 20 The Role of Preventive Interventions in Enhancing Neurocognitive Functioning and Promoting Competence in Adolescence - Conclusions
- Appendix A
- Appendix B
- Appendix C
- Index
- Plates
Transcriptional Regulation in Schizophrenia
Transcriptional Regulation in Schizophrenia
- Chapter:
- (p.103) Chapter 5 Transcriptional Regulation in Schizophrenia
- Source:
- Adolescent Psychopathology and the Developing Brain
- Author(s):
Scott E. Hemby
Joann A. O’Connor
- Publisher:
- Oxford University Press
Psychiatric diseases such as schizophrenia and autism spectrum disorders are generally considered to be neurodevelopmental in origin. Dysregulated gene and/or protein expression in the brain of adult schizophrenic patients must be understood in the context of a developmental model. This chapter discusses the basic mechanisms of transcriptional regulation and current knowledge of altered gene expression in schizophrenia focusing on glutamatergic and synaptic mechanisms. The relevance of these gene expression changes to neurodevelopment and other potential mechanisms of regulation in schizophrenia, and ideas about intervention to readjust dysregulated expression are considered.
Keywords: genetic influence, gene expression, autism, dysregulated expression
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- Title Pages
- Preface
- Introduction
-
Chapter 1 The Developing Brain and Adolescent-Typical Behavior Patterns -
Chapter 2 Competence, Resilience, and Development in Adolescence -
Chapter 3 Mapping Adolescent Brain Maturation Using Structural Magnetic Resonance Imaging -
Chapter 4 The Metamorphosis -
Chapter 5 Transcriptional Regulation in Schizophrenia -
Chapter 6 Stress Effects on the Developing Brain -
Chapter 7 Maternal Programming of Defensive Responses Through Sustained Effects on Gene Expression -
Chapter 8 Neuropeptides and the Development of Social Behaviors -
Chapter 9 The Effects of Early Deprivation on Brain-Behavioral Development -
Chapter 10 Social Stress, Affect, and Neural Function in Adolescence -
Chapter 11 Stress-Induced Pathophysiology Within the Schizophrenia Patient Brain -
Chapter 12 Neurohormones, Neurodevelopment, and the Prodrome of Psychosis in Adolescence -
Chapter 13 The Adolescent Surge in Depression and Emergence of Gender Differences -
Chapter 14 Early Identification and Prevention of Early-Onset Bipolar Disorder -
Chapter 15 Resilience and Vulnerability to Trauma -
Chapter 16 The Developing Adolescent Brain in Socioeconomic Context -
Chapter 17 Brain Development as a Vulnerability Factor in the Etiology of Substance Abuse and Addiction -
Chapter 18 Modifying Brain Networks Underlying Self-Regulation -
Chapter 19 The BrainWise Curriculum -
Chapter 20 The Role of Preventive Interventions in Enhancing Neurocognitive Functioning and Promoting Competence in Adolescence - Conclusions
- Appendix A
- Appendix B
- Appendix C
- Index
- Plates
