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Textbook of Cancer Epidemiology$
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Hans-Olov Adami, David Hunter, and Dimitrios Trichopoulos

Print publication date: 2008

Print ISBN-13: 9780195311174

Published to Oxford Scholarship Online: September 2009

DOI: 10.1093/acprof:oso/9780195311174.001.0001

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PRINTED FROM OXFORD SCHOLARSHIP ONLINE (oxford.universitypressscholarship.com). (c) Copyright Oxford University Press, 2021. All Rights Reserved. An individual user may print out a PDF of a single chapter of a monograph in OSO for personal use. date: 31 July 2021

The Origin of Cancer

The Origin of Cancer

(p.61) 3 The Origin of Cancer
Textbook of Cancer Epidemiology

Jeffrey Ecsedy

David Hunter

Oxford University Press

One of the major goals in cancer research is to elucidate the molecular and cellular events driving the progression of cells from a normal to a cancerous state. This transformation relies on the accumulation of mutations in various proto-oncogenes, tumor-suppressor genes, and DNA repair (caretaker) genes. Under normal circumstances, these genes participate in regulating cell and tissue behavior. However, progressive accumulation of mutations in these genes causes cells to transform to a malignant state. These mutations collaborate to overcome the numerous barriers and obstacles cells erect to prevent uncontrolled growth, including cell cycle control, absence of appropriate growth stimuli, programmed cell death, limited replicative potential, and immune-mediated eradication. In addition, these mutations ultimately result in altered interactions with the extracellular environment, facilitating tumor initiation and progression.

Keywords:   proto-oncogenes, tumor-suppressor genes, DNA repair, mutation, cell cycle, programmed cell death, initiation, progression

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