Jump to ContentJump to Main Navigation
Sex Differences in the BrainFrom Genes to Behavior$
Users without a subscription are not able to see the full content.

Jill B. Becker, Karen J. Berkley, Nori Geary, Elizabeth Hampson, James P. Herman, and Elizabeth Young

Print publication date: 2007

Print ISBN-13: 9780195311587

Published to Oxford Scholarship Online: January 2010

DOI: 10.1093/acprof:oso/9780195311587.001.0001

Show Summary Details
Page of

PRINTED FROM OXFORD SCHOLARSHIP ONLINE (oxford.universitypressscholarship.com). (c) Copyright Oxford University Press, 2021. All Rights Reserved. An individual user may print out a PDF of a single chapter of a monograph in OSO for personal use. date: 18 April 2021

Sex Differences in Pharmacogenomics as a Tool to Study CNS Disorders

Sex Differences in Pharmacogenomics as a Tool to Study CNS Disorders

(p.79) Chapter 5 Sex Differences in Pharmacogenomics as a Tool to Study CNS Disorders
Sex Differences in the Brain

Julia Pinsonneault

Wolfgang Sadée

Oxford University Press

This chapter reviews current trends in the understanding of the genetics of central nervous system (CNS) disorders and how sex differences impinge on outcomes, or can serve to study the underlying causes of disease. It shows that estrogens appear to play a prominent role, primarily as a protective agent in the case of schizophrenia and depression. Even in depression where women are more strongly affected than men, this may be due to a precipitous drop in estrogens, such as happens after delivering a baby or premenstrually. Yet, hormonal levels are but one of the multiple genomic differences between males and females. The chapter points out the overriding need to consider sex in understanding the disease and optimizing its therapy, but it also highlights the complexity of genomic factors in multigenic disease and therapy.

Keywords:   hormonal levels, central nervous system disorders, schizophrenia, depression, estrogen

Oxford Scholarship Online requires a subscription or purchase to access the full text of books within the service. Public users can however freely search the site and view the abstracts and keywords for each book and chapter.

Please, subscribe or login to access full text content.

If you think you should have access to this title, please contact your librarian.

To troubleshoot, please check our FAQs , and if you can't find the answer there, please contact us .