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Neurovascular MedicinePursuing Cellular Longevity for Healthy Aging$
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Kenneth Maiese

Print publication date: 2009

Print ISBN-13: 9780195326697

Published to Oxford Scholarship Online: January 2010

DOI: 10.1093/acprof:oso/9780195326697.001.0001

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PRINTED FROM OXFORD SCHOLARSHIP ONLINE (oxford.universitypressscholarship.com). (c) Copyright Oxford University Press, 2020. All Rights Reserved. An individual user may print out a PDF of a single chapter of a monograph in OSO for personal use. date: 02 December 2020

Role of Prion Protein During Normal Physiology and Disease

Role of Prion Protein During Normal Physiology and Disease

(p.3) Chapter 1 Role of Prion Protein During Normal Physiology and Disease
Neurovascular Medicine

Adriana Simon Coitinho

Glaucia N. M. Hajj

Oxford University Press

Prions are infectious particles composed only of proteins. Their importance resides in the concept that information transmission between two organisms can be devoid of nucleic acid. Prions are also well-known as the etiological agents of several neurodegenerative diseases of animals and humans called transmissible spongiform encephalopathies (TSEs). Literature on prion-associated diseases, transmission mechanisms, and the related normal isoform of the protein has grown impressively in the last few years, making it very difficult to cover all aspects of prion in depth in this chapter. This chapter therefore focuses on the history, symptoms, mechanisms of transmission and diagnosis of prion diseases, and currently proposed therapies. The roles of the normal isoform of the prion in physiology are also discussed, along with neuroinvasion and pathogenicity.

Keywords:   prion protein, prion diseases, transmissible spongiform encephalopathies, neurodegenerative diseases, physiology, neuroinvasion, pathogenicity

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