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Neurovascular MedicinePursuing Cellular Longevity for Healthy Aging$
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Kenneth Maiese

Print publication date: 2009

Print ISBN-13: 9780195326697

Published to Oxford Scholarship Online: January 2010

DOI: 10.1093/acprof:oso/9780195326697.001.0001

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Adult Neurogenesis, Neuroinflammation, and Therapeutic Potential of Adult Neural Stem Cells

Adult Neurogenesis, Neuroinflammation, and Therapeutic Potential of Adult Neural Stem Cells

Chapter:
(p.255) Chapter 10 Adult Neurogenesis, Neuroinflammation, and Therapeutic Potential of Adult Neural Stem Cells
Source:
Neurovascular Medicine
Author(s):

Philippe Taupin

Publisher:
Oxford University Press
DOI:10.1093/acprof:oso/9780195326697.003.0010

Contrary to a long-held dogma, neurogenesis occurs throughout adulthood in mammals, including humans. Neurogenesis occurs primarily in two regions of the adult brain, the hippocampus and the subventricular zone (SVZ), along the ventricles. Neural progenitor and stem cells have been isolated from various regions of the adult central nervous system (CNS) and characterized in vitro, providing evidence that neural stem cells reside in the adult CNS and are potential sources of tissue for therapy. Adult neurogenesis is modulated in animal models and patients with neurological diseases and disorders, such as Alzheimer's disease, depression, and epilepsy. The contribution of adult neurogenesis to neurological diseases and disorders, and its significance, remains to be elucidated. Cellular therapy may involve the stimulation of endogenous neural progenitor or stem cells and the grafting of neural progenitor and stem cells to restore the degenerated or injured pathways. Mounting evidence suggests that neuroinflammation is involved in the pathogenesis of neurological diseases and disorders.

Keywords:   cellular therapy, neurological diseases, neurogenesis, central nervous system, neuroinflammation, neural stem cells

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