Jump to ContentJump to Main Navigation
Neurovascular MedicinePursuing Cellular Longevity for Healthy Aging$
Users without a subscription are not able to see the full content.

Kenneth Maiese

Print publication date: 2009

Print ISBN-13: 9780195326697

Published to Oxford Scholarship Online: January 2010

DOI: 10.1093/acprof:oso/9780195326697.001.0001

Show Summary Details
Page of

PRINTED FROM OXFORD SCHOLARSHIP ONLINE (oxford.universitypressscholarship.com). (c) Copyright Oxford University Press, 2020. All Rights Reserved. An individual user may print out a PDF of a single chapter of a monograph in OSO for personal use. date: 05 December 2020

Redox Signaling and Vascular Function

Redox Signaling and Vascular Function

(p.473) Chapter 19 Redox Signaling and Vascular Function
Neurovascular Medicine

J. Will Langston

Magdalena L. Circu

Tak Yee Aw

Oxford University Press

Over the last two decades, reduction-oxidation (redox) signaling has emerged as an important regulator of cell function. The growing interest in the link between redox signaling and vascular function stems primarily from evidence that oxidative stress-induced endothelial dysfunction underlies a number of cardiovascular pathologies including hypertension, atherosclerosis, and diabetes, and that antioxidant intervention may be an important treatment modality in these vascular disorders. Of interest is the thiol antioxidant, reduced glutathione (GSH), a crucial regulator of cellular redox potential, and whose synthesis is transcriptionally upregulated under conditions of cellular oxidative stress. The transcriptional upregulation of the rate-limiting enzyme of GSH synthesis, glutamate cysteine ligase, under oxidative conditions by the transcription factor Nrf2 represents an important area of investigation in terms of its role in redox regulation of endothelial function, its role in vascular pathology, and its potential as a therapeutic target for treatment of cardiovascular disorders that involve vascular oxidative stress. This chapter discusses the roles of reactive oxygen species, redox regulation, and cell signaling in the vasculature. Redox activation of transcription factors in vascular disorders is also considered.

Keywords:   glutathione, redox signaling, vascular function, oxidative stress, cell signaling, reduction-oxidation, transcription factors, vascular disorders, vasculature, reactive oxygen species

Oxford Scholarship Online requires a subscription or purchase to access the full text of books within the service. Public users can however freely search the site and view the abstracts and keywords for each book and chapter.

Please, subscribe or login to access full text content.

If you think you should have access to this title, please contact your librarian.

To troubleshoot, please check our FAQs , and if you can't find the answer there, please contact us .