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Neurovascular MedicinePursuing Cellular Longevity for Healthy Aging$
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Kenneth Maiese

Print publication date: 2009

Print ISBN-13: 9780195326697

Published to Oxford Scholarship Online: January 2010

DOI: 10.1093/acprof:oso/9780195326697.001.0001

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Gene Therapy Toward Clinical Application in the Cardiovascular Field

Gene Therapy Toward Clinical Application in the Cardiovascular Field

(p.508) Chapter 20 Gene Therapy Toward Clinical Application in the Cardiovascular Field
Neurovascular Medicine

Hironori Nakagami

Mariana Kiomy Osako

Ryuichi Morishita

Oxford University Press

This chapter discusses the results of a study which assessed the potential of hepatocyte growth factor as a powerful angiogenic factor for treating peripheral arterial disease. It describes a novel strategy for combating the disease processes whereby the transcriptional process is targeted by transfection of cis-element double-stranded oligodeoxynucleotide (ODN), which served as a decoy. Transfection of decoy attenuates the authentic cis-trans interaction, leading to removal of trans-factors from the endogenous cis-elements and subsequent modulation of gene expression. A decoy was developed for nuclear factor κ B (NF-κB) that resulted in the inhibition of NF-κB-dependent gene activation including several kind of cytokines, chemokines, and adhesion molecules. In animal experiments, the transfection of NP-κB decoy into coronary artery decreased the infarction size in the ischemic-reperfusion rat myocardial infarction model, and also reduced the neointimal formation after balloon injury of rat carotid artery. Taken together with the results from other animal models, ODN decoy strategy has a great potential in gene therapy for cardiovascular diseases.

Keywords:   hepatocyte growth factor, oligodeoxynucleotide, cardiovascular diseases, peripheral arterial disease, gene therapy, decoy strategy, transfection

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