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Neurovascular MedicinePursuing Cellular Longevity for Healthy Aging$
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Kenneth Maiese

Print publication date: 2009

Print ISBN-13: 9780195326697

Published to Oxford Scholarship Online: January 2010

DOI: 10.1093/acprof:oso/9780195326697.001.0001

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Reducing Oxidative Stress and Enhancing Neurovascular Longevity During Diabetes Mellitus

Reducing Oxidative Stress and Enhancing Neurovascular Longevity During Diabetes Mellitus

(p.540) Chapter 22 Reducing Oxidative Stress and Enhancing Neurovascular Longevity During Diabetes Mellitus
Neurovascular Medicine

Kenneth Maiese

Zhao Zhong Chong

Faqi Li

Oxford University Press

This concluding chapter looks at the raves and risks of novel therapeutic strategies that are translational in nature by focusing on the complications of oxidative stress and diabetes mellitus (DM) in the neuronal and vascular systems. Both type 1 and type 2 DM can lead to significant disability in the nervous and cardiovascular systems, such as cognitive loss and cardiac insufficiency. Innovative strategies that directly target oxidative stress to preserve neuronal and vascular longevity could offer viable therapeutic options to diabetic patients in addition to the more conventional treatments that are designed to control serum glucose levels. This chapter explores the novel applications of nicotinamide, Wnt signaling, and erythropoietin (EPO) that modulate cellular oxidative stress and offer significant promise for the prevention of diabetic complications in the neurovascular systems. Essential to this process is the precise focus on the cellular pathways governed by nicotinamide, Wnt signaling, and EPO to avoid detrimental clinical complications and offer the development of effective and safe future therapy for patients.

Keywords:   diabetes mellitus, oxidative stress, Wnt signaling, erythropoietin, nicotinamide, neurovascular systems, longevity

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