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Neurovascular MedicinePursuing Cellular Longevity for Healthy Aging$
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Kenneth Maiese

Print publication date: 2009

Print ISBN-13: 9780195326697

Published to Oxford Scholarship Online: January 2010

DOI: 10.1093/acprof:oso/9780195326697.001.0001

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Brain Temperature Regulation During Normal Neural Function and Neuropathology

Brain Temperature Regulation During Normal Neural Function and Neuropathology

(p.46) Chapter 3 Brain Temperature Regulation During Normal Neural Function and Neuropathology
Neurovascular Medicine

Eugene A. Kiyatkin

Oxford University Press

This chapter deals with brain temperature as a physiological parameter, which is determined primarily by neural metabolism, regulated by cerebral blood flow, and affected by various environmental factors and drugs. First, normal fluctuations in brain temperature that are induced by salient environmental stimuli and occur during motivated behavior at stable normothermic conditions are examined. On the basis of thermorecording data obtained in animals, the range of physiological fluctuations in brain temperature, their underlying mechanisms, and relations to body temperatures are described. The temperature dependence of neural activity and the dual “functions” of temperature as a reflection of metabolic brain activity and as a factor that affects this activity are considered. Third, pharmacological brain hyperthermia is discussed, focusing on the effects of psychomotor stimulants, highly popular drugs of abuse that increase brain metabolism, diminish heat dissipation, and may induce pathological brain overheating. The role of brain hyperthermia in leakage of the blood-brain barrier, development of brain edema, acute abnormalities of neural cells, and neurotoxicity, is also examined.

Keywords:   metabolism, cerebral blood flow, hyperthermia, brain temperature, behavior, psychomotor stimulants, blood-brain barrier, edema, neurotoxicity, neuropathology

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