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Neurovascular MedicinePursuing Cellular Longevity for Healthy Aging$
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Kenneth Maiese

Print publication date: 2009

Print ISBN-13: 9780195326697

Published to Oxford Scholarship Online: January 2010

DOI: 10.1093/acprof:oso/9780195326697.001.0001

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Motoneurons from Human Embryonic Stem Cells: Present Status and Future Strategies for their Use in Regenerative Medicine

Motoneurons from Human Embryonic Stem Cells: Present Status and Future Strategies for their Use in Regenerative Medicine

Chapter:
(p.231) Chapter 9 Motoneurons from Human Embryonic Stem Cells: Present Status and Future Strategies for their Use in Regenerative Medicine
Source:
Neurovascular Medicine
Author(s):

K. S Sidhu

Publisher:
Oxford University Press
DOI:10.1093/acprof:oso/9780195326697.003.0009

Human embryonic stem cells are pluripotent and can produce the entire range of major somatic cell lineage of the central nervous system and thus form an important source for cell-based therapy of various neurological diseases. Despite their potential use in regenerative medicine, the progress is hampered by difficulty in their use because of safety issues and lack of proper protocols to obtain purified populations of specified neuronal cells. Most neurological conditions such as spinal cord injury and Parkinson's disease involve damages to projection neurons. Similarly, certain cell populations may be depleted after repeated episodes of attacks such as the myelinating oligodendrocytes in multiple sclerosis. Motoneurons are the key effector cell type for control of motor function, and loss of motoneurons is associated with a number of debilitating diseases such as amyotrophic lateral sclerosis and spinal muscular atrophy; hence, repair of such neurological conditions may require transplantation with exogenous cells.

Keywords:   central nervous system, motoneurons, cell transplantation, cell-based therapy, regenerative medicine, human embryonic stem cells

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