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Imaging the Aging Brain$
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William Jagust and Mark D'Esposito

Print publication date: 2009

Print ISBN-13: 9780195328875

Published to Oxford Scholarship Online: February 2010

DOI: 10.1093/acprof:oso/9780195328875.001.0001

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Introduction: Still More Questions than Answers

Introduction: Still More Questions than Answers

(p.3) 1 Introduction: Still More Questions than Answers
Imaging the Aging Brain

William Jagust

Mark D’Esposito

Oxford University Press

Brain imaging has become widely applied to the study of aging because of substantial advances in technology and the diffusion of this technology throughout the world of human neuroscience. These advances together with better clinical characterization and more sophisticated molecular approaches now permit us to better understand relationships between brain aging and brain disease. In this setting, the concept of “normal aging” may become better defined by our ability to clearly characterize chemistry, anatomy, and physiology of the aging brain using multimodal approaches. Future directions for this cognitive neuroscience of aging will be the detection of presymptomatic forms of age-related disease, understanding how different diseases interact in normal older people, and the definition of age-related processes that are independent of disease and that affect specific cognitive, anatomic, and neurochemical systems.

Keywords:   imaging, technology, normal aging, cognitive neuroscience, presymptomatic, multimodal

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