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Imaging the Aging Brain$
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William Jagust and Mark D'Esposito

Print publication date: 2009

Print ISBN-13: 9780195328875

Published to Oxford Scholarship Online: February 2010

DOI: 10.1093/acprof:oso/9780195328875.001.0001

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PRINTED FROM OXFORD SCHOLARSHIP ONLINE (oxford.universitypressscholarship.com). (c) Copyright Oxford University Press, 2021. All Rights Reserved. An individual user may print out a PDF of a single chapter of a monograph in OSO for personal use. date: 24 October 2021

Functional Imaging with FDG-PET in Mild Cognitive Impairment

Functional Imaging with FDG-PET in Mild Cognitive Impairment

(p.183) 13 Functional Imaging with FDG-PET in Mild Cognitive Impairment
Imaging the Aging Brain

Karl Herholz

Oxford University Press

Assessment of regional cerebral glucose metabolism by FDG-PET at the resting state is a standard functional technique to assess cerebral function. An increasing body of evidence indicates that substantial impairment of FDG uptake in temporo-parietal association cortices is a reliable predictor of rapid progression to dementia in patients with mild cognitive impairment (MCI). The definition of affected and reference regions, the methods for quantitative analysis, and other methodological issues that are relevant for use of the method in clinical studies are being addressed. Effects of aging, the selection of normal controls, and interaction with age and genetic risk factors are important factors that also need to be considered in designing and interpreting studies.

Keywords:   positron emission tomography, 18F-fluorodeoxyglucose, cerebral glucose metabolism, standardized image analysis, prediction of progression

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