Jump to ContentJump to Main Navigation
Neuroimaging in Epilepsy$
Users without a subscription are not able to see the full content.

Harry Chugani, MD

Print publication date: 2010

Print ISBN-13: 9780195342765

Published to Oxford Scholarship Online: January 2011

DOI: 10.1093/acprof:oso/9780195342765.001.0001

Show Summary Details
Page of

PRINTED FROM OXFORD SCHOLARSHIP ONLINE (oxford.universitypressscholarship.com). (c) Copyright Oxford University Press, 2021. All Rights Reserved. An individual user may print out a PDF of a single chapter of a monograph in OSO for personal use. date: 18 January 2021

Malformations of Cortical Development

Malformations of Cortical Development

(p.37) Chapter 3 Malformations of Cortical Development
Neuroimaging in Epilepsy

Renzo Guerrini

Francesco Zellini

Oxford University Press

Abnormal cortical development represents a major cause of epilepsy. Most such abnormalities may now be detected using magnetic resonance imaging (MRI), although some remain undetectable even with the best imaging techniques. The largest malformation groups express different perturbations of developmental stages and carry a variable propensity to epileptogenesis, preservation or reorganization of cortical function and for atypical cortical organization. Some patients have obvious neurological impairment, whereas others show unexpected deficits that are detectable only by screening. Drug-resistant epilepsy is frequent but might be amenable to surgical treatment in some patients. Surgical planning should be based on assessments of structural, and if possible functional imaging, as well as clinical and electrographic features. Most malformations of cortical development are caused by genetic defects and brain imaging has been instrumental to the identification of causative genes. Nowadays many patients with epilepsy due to malformations of cortical development can be offered genetic counseling.

Keywords:   magnetic resonance imaging, neuronal migration, cortical dysplasia, heterotopia, lissencephaly, polymicrogyria, epilepsy, seizures cognitive impairment, genetics

Oxford Scholarship Online requires a subscription or purchase to access the full text of books within the service. Public users can however freely search the site and view the abstracts and keywords for each book and chapter.

Please, subscribe or login to access full text content.

If you think you should have access to this title, please contact your librarian.

To troubleshoot, please check our FAQs , and if you can't find the answer there, please contact us .